Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

Table 2 Effects of exercise, L-dopa and their combination on gait measured by Foot print test (overlap, front stride width, front stride length, hind stride width and hind stride length in cm)

Group	Control G	Rotenone G	Rotenone\ exercise G	Rotenone\L-dopa G	Combined G	P- value by ANOVA
OL	1.50 ± 0.3	2.10 ± 0.45	1.40 ± 0.3	1.35 ± 0.2	1.55 ± 0.3	0.0008
OL	1.50 ± 0.3	*P = 0.001	^#P = 0.001	^#P = 0.0001	^#P = 0.003	0.0008
FSW	4.95 ± 1.23	5.95 ± 0.83	3.40 ± 0.99	5.20 ± 0.91	4.15 ± 0.8	0.006
FSW	4.95 ± 1.23	*P = 0.02	^#P = 0.007	P = 0.12	^#P = 0.009	0.006
FSL	11.89 ± 1.8	9.70 ± 1.65	13.5 ± 3.2	13.1 ± 1.44	11.1 ± 2.5	0.002
FSL	11.89 ± 1.8	*P = 0.01	^#P = 0.001	^#P = 0.006	^#P = 0.003	0.002
HSW	6.15 ± 0.78	7.00 ± 0.88	4.55 ± 1.2	6.15 ± 0.78	5.65 ± 0.7	0.001
HSW	6.15 ± 0.78	*P = 0.004	^#P < = 0.001	P = 0.08	^#P = 0.002	0.001
HSL	12.65 ± 1.6	10.1 ± 1.46	12.8 ± 1.53	13.5 ± 1.24	11.7 ± 2.5	0.001
HSL	12.65 ± 1.6	*P= 0.02	^#P=0.002	^#P=0.001	^#P=0.03	0.001

P value is calculated by ANOVA test, and is considered significant if < 0.05. n = 10 in each group. Data was expressed as mean ± SD
OL overlap, FSW front stride width, FSL front stride length, HSW hind stride width, HSL hind stride length
*significant when compared to control group. ^#significant when compared to rotenone group

ISSN: 1744-9081