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Fig. 4 | Behavioral and Brain Functions

Fig. 4

From: Susceptibility to chronic immobilization stress‐induced depressive-like behaviour in middle‐aged female mice and accompanying changes in dopamine D1 and GABAA receptors in related brain regions

Fig. 4

Changes in the mRNA level of GABRA1 in the nucleus accumbens (NAc) and prefrontal cortex (PFC). The data are presented as the mean ± SEM. a GABRA1 expression in the NAc. b GABRA1 expression in the PFC. Age could directly induce a decrease in the mRNA level of GABRA1 in the NAc and PFC in mice in the absence of stress. Moreover, CIS could induce a reduction in the mRNA level of GABRA1 in the PFC in young mice but not middle-aged mice. *P < 0.05 compared with the age-matched control group; #P < 0.05 compared with young mice subjected to the same treatment. Two-way ANOVA followed by the LSD post hoc multiple comparisons test

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