The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study

Table 2 Results of regression analysis (seizure severity and seizure duration) in the different groups

Variable		B	SE	t	p-value
Severity of seizures	Naloxone vs tramadol	− 0.40	0.18	2.19	0.03
	Diazepam vs tramadol	− 0.85	0.18	2.19	< 0.001
	Naloxone-diazepam vs tramadol	− 1.55	0.33	− 4.65	< 0.001
	Acute quercetin vs tramadol	− 0.21	0.16	1.29	0.20
	Chronic quercetin vs tramadol	0.04	0.18	0.23	0.81
	Quercetin-naloxone vs tramadol	0.01	0.21	0.07	0.94
	Tramadol vs control	3.05	0.37	8.16	< 0.001
	Naloxone vs control	2.65	0.37	7.22	< 0.001
	Diazepam vs control	2.20	0.36	5.98	< 0.001
	Naloxone-diazepam vs control	1.50	0.46	3.27	0.001
	Acute quercetin vs control	2.84	0.35	7.93	< 0.001
	Chronic quercetin vs control	3.07	0.36	8.47	< 0.001
	Quercetin-naloxone vs control	3.09	0.38	8.05	< 0.001
Duration of seizures	Naloxone vs tramadol	− 4.22	1.13	− 3.73	< 0.001
	Diazepam vs tramadol	− 3.78	1.14	− 3.32	< 0.001
	Naloxone-diazepam vs tramadol	− 3.15	2.05	− 1.54	0.12
	Acute quercetin vs tramadol	− 5.20	1.02	− 5.11	< 0.001
	Chronic quercetin vs tramadol	− 1.69	1.11	− 1.52	0.13
	Quercetin-naloxone vs tramadol	− 0.61	1.29	− 0.48	0.63
	Tramadol vs control	7.07	2.29	3.09	0.002
	Naloxone vs control	2.84	2.24	1.27	0.20
	Diazepam vs control	3.29	2.25	1.46	0.14
	Naloxone-diazepam vs control	3.92	2.81	1.39	0.16
	Acute quercetin vs control	1.87	2.19	0.85	0.39
	Chronic quercetin vs control	5.37	2.24	2.40	0.02
	Quercetin-naloxone vs control	6.45	2.33	2.77	0.005

ISSN: 1744-9081