The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study

Table 3 Comparison of sedation levels in the different groups vs the Control and Tramadol groups based on the GEE model

Groups	B	SE	Wald	p-value
Tramadol vs control	0.59	0.04	192.53	< 0.001
Naloxone vs control	0.56	0.04	162.00	< 0.001
Diazepam vs control	0.59	0.04	192.53	< 0.001
Naloxone-diazepam vs control	0.64	0.06	100.04	< 0.001
Acute quercetin vs control	0.67	0.07	93.03	< 0.001
Chronic quercetin vs control	0.64	0.04	194.32	< 0.001
Quercetin-naloxone vs control	0.70	0.07	113.28	< 0.001
Naloxone vs tramadol	− 0.03	0.06	0.25	0.61
Diazepam vs tramadol	− 5.06 e−18	0.06	0.0001	1.00
Naloxone-diazepam vs tramadol	0.04	0.08	0.32	0.57
Acute quercetin vs tramadol	0.08	0.08	0.91	0.34
Chronic quercetin vs tramadol	0.04	0.06	0.52	0.47
Quercetin-naloxone vs tramadol	0.11	0.07	1.93	0.16

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