Table 4 Comparison of mean sedation levels in the different treatment groups during the 6-h course following tramadol administration
Groups/times | 15Â min | 30Â min | 1Â h | 2Â h | 3Â h | 4Â h | 5Â h | 6Â h |
|---|---|---|---|---|---|---|---|---|
Control | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Tramadol | 1.0 ± 0.0 | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.0 ± 0.0 | 0.1 ± 0.3 | 0.1 ± 0.3 | 0 ± 0 | 0 ± 0 |
Naloxone | 1.0 ± 0.0 | 1.3 ± 0.4 | 1.3 ± 0.4 | 0.8 ± 0.3 | 0.1 ± 0.3 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Diazepam | 1.1 ± 0.4 | 1.3 ± 0.4 | 1.4 ± 0.5 | 1 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Naloxone-diazepam | 1.0 ± 0.0 | 1.1 ± 0.3 | 1.3 ± 0.5 | 1.3 ± 0.5 | 0.3 ± 0.4 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Acute quercetin | 1.0 ± 0.0 | 1.5 ± 0.5 | 1.3 ± 0.4 | 1.0 ± 0.5 | 0.4 ± 0.5 | 0.1 ± 0.3 | 0.1 ± 0.3 | 0 ± 0 |
Chronic quercetin | 1.1 ± 0.3 | 1.2 ± 0.4 | 1.4 ± 0.5 | 1.1 ± 0.3 | 0.2 ± 0.4 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Quercetin-naloxone | 1.0 ± 0.0 | 1.2 ± 0.4 | 1.5 ± 0.5 | 1.3 ± 0.4 | 0.4 ± 0.5 | 0.1 ± 0.3 | 0.1 ± 0.3 | 0 ± 0 |
Test results | F = 35.6 P = 0.0 | F = 8.1 P = 0.0 | F = 8.9 P = 0.0 | F = 7.8 P = 0.0 | F = 1 P = 0.4 | F = 0.7 P = 0.6 | F = 0.8 P = 0.5 |  |