Table 5 Relevant shared gene correlates for DCX, COMT and FMR1
From: Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment
COMT +/DCX − | |
BCAP31 | Apoptosis, ubiquitin dependent catabolic process protein transport, X-linked mental retardation, dystonia, cerebral hypomyelination |
BCL11B | Neurogenesis, axon guidance, neuron projection, transcription, splicing, methylation |
GNA14 | Signal transduction phospholipase C-activating dopamine receptor signaling pathway |
HAP1 | Synaptic transmission axonal transport, cerebellum development, cell projection organization, neurogenesis, transport along microtubules |
KREMEN2 | Wnt signalling |
COMT −/DCX + | |
AUTS2 | Transcription regulation, Autism, mental retardation/ID |
BZW2 | Nervous system development, cell–cell adhesion, neurogenesis |
CELSR3 | Neuron migration, axonal fasciculation, dopaminergic serotonergic neuron axon guidance, Wnt signaling pathway |
CEP120 | Regulation of centrosome duplication, cerebral cortex development, neurogenesis, astral microtubule organization |
CHAMP1 | Protein localization to kinetochore, protein localization to microtubule, attachment of mitotic spindle microtubules to kinetochore |
CSNK1G1 | Endocytosis, regulation of cell shape, Wnt and Hedgehog signaling |
CTCF | Transcription regulation, DNA methylation, mental retardation, Mental retardation, autosomal dominant 21 |
DACT1 | Transcription regulation, Wnt signaling |
EFNB2 | Cell adhesion, axon guidance, neurogenesis |
EML1 | Microtubule cytoskeleton organization, epilepsy, mental retardation |
FAT4 | Neurogenesis, cerebral cortex development, cell adhesion, mental retardation/ID |
FXR2 | RNA transport, negative regulation of translation, Fragile X mental retardation |
GATAD2B | Transcription, DNA methylation, mental retardation/ID |
HDAC2 | Transcription regulation, chromatin remodeling neuron projection and dendrite development |
KIAA2022 | Nervous system development, X-linked mental retardation, neurogenesis mental retardation, X-linked 98, neurite extension and migration |
KIDINS220 | Dendrite morphogenesis, neuron projection development, neurogenesis |
MCPH1 | Mitotic spindle orientation, regulation of gene expression, cerebral cortex development, mental retardation, Microcephaly 1, primary, autosomal recessive |
SEMA3A | Neuron migration, axon guidance, neurogenesis |
SEMA3C | Neuron migration, axon guidance, neurogenesis |
SETBP1 | DNA binding, Schinzel-Giedion midface retraction syndrome, mental retardation, autosomal dominant 29 |
STMN1 | Microtubule depolymerization, mitotic spindle organization, axongenesis, neurogenesis |
TAF2 | Transcription regulation, mental retardation/ID Mental retardation, autosomal recessive 40 |
TCF4 | Transcription regulation, neurogenesis, epilepsy, mental retardation, Pitt-Hopkins syndrome |
XRCC5 | Transcription, DNA recombination, neurogenesis |
FMR1 +/COMT − | |
ATRX | DNA methylation, chromatin remodeling, transcription, Mental retardation: alpha-thalassemia/mental retardation syndrome, mental retardation-hypotonic facies syndrome, X-linked 52/intellectual development disorder |
BRWD3 | Transcription regulation, mental retardation X-linked intellectual developmental disorder |
EIF2AK4 | Translation, ribosome structure and biogenesis, learning and long-term memory |
NUFIP1 | RNA processing, transcription fragile X mental retardation-interacting protein 1 |
PCM1 | Neuron migration, microtubule organization and anchoring, social behavior, negative regulation of neurogenesis |
TTC21B | Transcription regulator, smoothened signaling pathway regulation |
FMR1 −/COMT + | |
GAS6 | Dendritic cell differentiation, apoptosis |
KIF19 | Axon, microtubule depolymeriation |
NDUFS7 | Synapse, neuron projection |