Fig. 3

Administration of a complete PUFA diet from 1 month of age in Elovl5^−/− and wild type mice. A Scheme of diet administration: one group composed of Elovl5^−/− (n = 20) and wild type mice (n = 19) received a diet providing them with both Elovl5 substrates and downstream products from 1 month of age (complete PUFA diet), while the other group of Elovl5^−/− (n = 18) and wild type mice (n = 20) received PUFA precursors only from birth (PUFA precursors only). B, C Bar graphs showing errors committed at 6 months of age when traversing the experimental apparatus for wild type and Elovl5^−/−mice who received the complete diet since 1 month of age compared to the group receiving the precursor diet only (for wild type mice: **P < 0.01, Unpaired Student’s t-test; for Elovl5^−/−mice P > 0.05, Unpaired Student’s t-test). D, E Bar graphs showing errors committed at 8 months of age when traversing the experimental apparatus by wild type and Elovl5^−/− mice receiving the two different diets (for wild type mice: **P < 0.01, Unpaired Student’s t-test; for Elovl5^−/−mice P = 0.07, Unpaired Student’s t-test). Values are mean ± S.E.M