A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions

Table 1 Descriptive statistics for the investigated traits in the study sample. POE: parent-of-origin effect

Trait	Domain	The function measured by the test	Descriptive statistics for phenotypes in the full sample							General test^a		Paternal POE test^b		Maternal POE test^b
Trait	Domain	The function measured by the test	Children with phenotype data	Mean	Median	Standard deviation	Minimum value	Maximum value	Shapiro–Wilk test p-value	Minimum Number of probands	Maximum Number of probands	Minimum Number of probands	Maximum Number of probands	Minimum Number of probands	Maximum Number of probands
MABC	Motor	A combined score from tests of manual dexterity, aiming and catching, and balance	399	8.105	8	3.31	1	19	0.0001	337	399	196	382	196	382
WISC Coding	Neurocognitive	Processing speed	401	− 0.134	− 0.059	0.992	− 3.61	3.219	0.0417	338	401	197	384	197	384
WISC Symbol Search	Neurocognitive	Processing speed	398	− 0.121	− 0.073	0.994	− 3.292	2.767	8.74 × 10^–5	335	398	196	381	196	381
SSR	Social-cognitive	Theory of mind	400	− 0.1	0.046	0.999	− 3.227	2.909	1.69 × 10^–6	337	400	197	383	197	383
SRS	Social-behavioral	Social responsiveness	345	49.014	46	10.441	37	106	4.68 × 10^–19	292	345	172	331	172	331
WISC Arithmetic	Neurocognitive	Verbal working memory	398	9.475	10	2.396	2	15	1.18 × 10^–10	335	398	196	381	196	381
WISC Letter-Number Sequencing	Neurocognitive	Verbal working memory	398	10.508	11	3.103	1	16	7.34 × 10^–13	336	398	196	381	196	381
RIST Index	Neurocognitive	A combined score from tests of non-verbal intelligence (approximation of fluid intelligence) and verbal intelligence (a measure of crystallized intelligence)	401	103.85	105	10.458	56	127	5.75 × 10^–10	338	401	198	384	198	384

^aQTDT chooses informative probands from the pedigree file. Additionally, probands could have been excluded from the tests based on phenotype missingness, genotype missingness and/or problems with their IBD estimation with MERLIN
^bIn addition to the reasons for exclusion in the general test, probands could have also been excluded based on parental genotypes (see “Materials and methods”)

ISSN: 1744-9081