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Fig. 3 | Behavioral and Brain Functions

Fig. 3

From: Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals

Fig. 3

Anxiety-like behaviors in SPS rats subjected to fluoxetine and treadmill exercise as assessed in the elevated plus maze. Exercise and fluoxetine combination groups showed reduction in anxiety level in both groups. SPS groups showed reductions in open arm Time (OAT, A) and open arm Entry (OAE, B). A *sham/SED-VEH vs SPS/SED-VEH (P = 0.002). **Sham/EXC-FLX vs sham/SED-VEH (P = 0.0001). ***Sham/EXC-FLX vs Sham/SED-FLX (P = 0.004). ****Sham/EXC-VEH vs SPS/EXC-VEH (P = 0.0001). *****SPS/EXC-FLX vs Sham/EXC-FLX (P = 0.0001). ******SPS/EXC-FLX vs SPS/SED-VEH (P = 0.0001). B *SPS/ SED-VEH vs Sham/ SED-VEH (P = 0.0001). **ham/EXC-FLX vs Sham/ SED-VEH (P = 0.046). ***SPS/ EXC-VEH and SPS/ SED-FLX and SPS/ EXC-FLX (P = 0.0001) vs SPS/ SED-VEH. ****SPS/SED-FLX vs Sham/ SED-FLX (P = 0.0001). *****SPS/EXC-VEH vs Sham/ EXC-VEH (P = 0.023). ******SPS/EXC-FLX vs Sham/ EXC-FLX (P = 0.0001)

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Behavioral and Brain Functions

ISSN: 1744-9081

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