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Fig. 4 | Behavioral and Brain Functions

Fig. 4

From: Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals

Fig. 4

Fear conditioning and extinction index in SPS rats subjected to fluoxetine and treadmill exercise as assessed in extinction test. A (Entrance latency time) Exercise and fluoxetine combination groups showed reduction in entrance latency time in both groups. SPS groups showed increased entrance latency time in conditioning phase and in 1th, 2th, 3th, and 4th extinction. In conditioning phase *SPS/SED-VEH vs Sham/SED-VEH (P = 0.001). **SPS/EXC-FLX and SPS/EXC-VEH vs SPS/SED-VEH (P = 0.0001). In 1th extinction **SPS/EXC-FLX, (P = 0.0001) and SPS /EXC-VEH (P = 0.007) vs SPS /SED-VEH. **SPS/SED-FLX vs Sham/SED-FLX (P = 0.002). In 2th extinction*SPS/SED-VEH vs Sham/SED-VEH (P = 0.038). **SPS/EXC-FLX (P = 0.0001), SPS/SED-FLX (P = 0.050), and SPS/EXC-VEH (P = 0.001) vs SPS/SED-VEH. In 3th extinction *SPS/SED-VEH vs Sham/SED-VEH (P = 0.0001). **SPS/EXC-FLX (P = 0.0001), SPS/SED-FLX (P = 0.011) and SPS/EXC-VEH (P = 0.003) vs SPS/SED-VEH. In 4th extinction *SPS/SED-VEH vs Sham/SED-VEH (P = 0.0001). **SPS/EXC-FLX (P = 0.0001), SPS/SED-FLX (P = 0.050) and SPS/EXC-VEH (P = 0.0001) vs SPS/SED-VEH. B (Extinction index) *SPS/SED-VEH vs sham/SED-VEH group (P = 0.0001), **SPS/SED-FLX (P = 0.002), SPS/EXC-VEH (P = 0.0001), and SPS/EXC-FLX (P = 0.0001) vs SPS/SED-VEH

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