Fig. 6

Examination for IgG deposition in the choroid plexus and lateral ventricular wall. A, C Representative images of the choroid plexus and lateral ventricular wall stained with H&E. B, D Representative images of IgG deposition in the choroid plexus and lateral ventricular wall. White square showing the co-localization of an enlarged Iba-1-immunoreactive microglia (green) and IgG (red). DAPI staining for nuclei (blue). E, F Quantitative analysis of IgG deposition in the choroid plexus (p < 0.0001, < 0.0001, < 0.0001) and lateral ventricular wall (p < 0.0001, < 0.0001, < 0.0001) by MFI. The data are expressed as the mean ± SEM (n = 12 in each group). Two-way ANOVA followed by Tukey’s post hoc test or Scheirer–Ray–Hare test: **p < 0.01