Fig. 2

Mice were divided into the following treatment groups: Control (CTRL) (n = 12), OEA-C (n = 15) received 10 mg/kg OEA pre-treatment before each conditioning session, OEA-EXT (n = 15) received 10 mg/kg OEA pre-treatment before each extinction session and OEA-REINST (n = 13) received 10 mg/kg OEA pre-treatment before the single reinstatement test. Data presented as mean values ± S.E.M. of the time spent in the drug-paired compartment on the Pre-C test (white bars), Post-C test (dark gray bars), in the last extinction sessions (light gray bars) and during the reinstatement tests with 5 mg/kg of cocaine (striped gray bars). ***p < 0.001, ** p < 0.01, * p < 0.05 significant difference in the time spent in the drug-paired compartment vs. pre-conditioning test