Fig. 3

Impaired learning and spatial memory in mice 7 months after intra-hippocampal cis P-tau injection. Graphs shows the effect of intra-hippocampal cis P-tau injection on primary latency A total latency B primary errors C total errors D traveled distance E velocity F strategy G and hole exploration frequency in the goal sector (GS) I non-goal sector (NGS) J GS/NGS ratio K and target-seeking activity L in the Barnes maze test at 7 months after cis P-tau injection compared to the control group. All data represent mean ± SEM. * P < 0.05, ** P < 0.01, and *** P < 0.001. Color maps M shows the percent time in each location of the maze on the probe day in control and cis P-tau groups. A sample of exploration path of animals in control and cis P-tau groups on the probe day is also showing N. The black circle marks the location of the escape box in M and N