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Table 1 Effect sizes (beta) per minor allele copy for RGS4 gene SNPs

From: Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level

 

rs10917670

per A allele copy

rs951436

per G allele copy

rs2661319

per G allele copy

Response

N

beta

Pall-load(P ANOVA )

N

beta

Pall-load(P ANOVA )

N

beta

Pall-load(P ANOVA )

IQ (RPM)

1470

-0.39

0.235 (0.349)

1595

0.17

0.603 (0.799)

1411

0.10

0.773 (0.715)

SPQ total score

1043

0.49

0.363 (0.607)

1134

-0.65

0.215 (0.455)

1004

-0.64

0.246 (0.502)

SPQ cognitive/perceptual factor

1041

0.00

0.553 (0.839)

1132

-0.00

0.807 (0.966)

1002

-0.00

0.514 (0.795)

SPQ negative factor

1041

0.01

0.184 (0.291)

1132

-0.01

0.009 (0.031)

1002

-0.01

0.039 (0.117)

SPQ disorganization factor

1041

0.01

0.256 (0.493)

1132

-0.01

0.266 (0.538)

1002

-0.01

0.262 (0.493)

SPQ paranoid factor

1041

0.00

0.980 (0.876)

1132

0.00

0.908 (0.881)

1002

0.00

0.896 (0.976)

d'-S2B (spatial working memory)

1434

-0.06

0.153 (0.352)

1558

-0.02

0.514 (0.650)

1384

-0.02

0.682 (0.900)

d'-V2B (verbal working memory)

1372

-0.05

0.124 (0.306)

1494

0.02

0.556 (0.285)

1324

0.01

0.755 (0.785)

Antisaccade error rate

1585

0.01

0.286 (0.565)

1731

-0.01

0.069 (0.173)

1532

-0.02

0.028 (0.089)

  1. SNP, single nucleotide polymorphism; ANOVA, analysis of variance; Pall-load, p value for the allele-load model; PANOVA, ANOVA p value. Strong linkage disequilibrium was observed between rs10917670 and rs951439 (r2 = 0.98). Results of rs951439 are not shown but are similar to rs 10917670.