Figure 2

Acquisition, extinction and reinstatement of 1.25 mg/kg MDMA- and WIN-induced CPP. Acquisition, extinction and reinstatement of MDMA- and WIN-induced CPP in six groups of animals: SAL, animals receiving saline in both compartments (n = 10); MDMA 1.25, animals receiving 1.25 mg/kg of MDMA in the drug-paired compartment (n = 10); MDMA 1.25 + WIN 0.5 and MDMA 1.25 + WIN 0.1 animals receiving 0.5 or 0.1 mg/kg of WIN plus 1.25 mg/kg of MDMA in the drug-paired compartment (n = 11); MDMA 1.25 + SR 3 + WIN 0.1, animals conditioned with 1.25 mg/kg of MDMA plus 3 mg/kg of SR plus 0.1 mg/kg of WIN (n = 14). The bars represent the mean (± SEM) time spent in the drug-paired compartment before conditioning sessions (white bars), after conditioning sessions (blue bars), in the last extinction session (light blue bars) and in the reinstatement test (dark blue bars). ** p < 0.02 significant difference in the time spent in pre-conditioning vs. post-conditioning sessions or reinstatement tests.