Haplotype | Frequency | Case, control ratios | χ2 | P-value |
---|
A-A-A-G | 0.206 | 0.217, 0.194 | 0.26 | 0.610 |
C-A-C-G 1 | 0.177 | 0.121, 0.241 | 7.79 |
0.005
|
A-G-A-G | 0.177 | 0.146, 0.212 | 2.36 | 0.124 |
A-G-A-T | 0.139 | 0.114, 0.167 | 1.81 | 0.178 |
C-A-A-G | 0.126 | 0.138, 0.112 | 0.49 | 0.484 |
A-A-A-T 1 | 0.094 | 0.147, 0.035 | 11.46 |
0.0007
|
A-A-C-T | 0.020 | 0.033, 0.005 | 3.12 | 0.077 |
A-G-C-G | 0.019 | 0.017, 0.022 | 0.10 | 0.752 |
A-A-C-G | 0.017 | 0.024, 0.008 | 1.25 | 0.263 |
C-G-A-T | 0.012 | 0.022, 0.002 | 2.52 | 0.112 |
- SNP, single nucleotide polymorphism.
- Case refers to patients with schizophrenia, and control refers to control subjects.
- Haplotypes listed are only those with a frequency ≥1%.
- The P-values given are based on 10000 permutations using the Haploview program.
- Associations reaching nominal significance (P < 0.05) are shown in bold.
- 1Note that C-A-C-G haplotype is an allelic opposite at all, but the second, loci of A-A-A-T haplotype. C-G-C-G haplotype that is the exact allelic opposite of A-A-A-T haplotype was absent in our patient and control populations.