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Table 3 SPM analyses performed in the subgroup of 19 women after the exclusion of the homozygote carriers of the S allele of the 5-HTTLPR polymorphism.

From: 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study

 

19 women

contrast

Anatomic brain regions covered

MNI coordinates (x, y, z (mm))

Z score, k, p

GG-CC

bulbar serotoninergic nuclei

0; -22; -46

Z = 4.75, k = 244, p = 0.021*

 

left superior and middle frontal gyri (F1 and F2)

-16; 18; 50

Z = 4.73, k = 480, p = 0.001*

 

right mesial frontal and left supplementary motor area

2; -14; 58

Z = 4.55, k = 885, p < 0.001*

 

left and right mesial frontal pole

-2; 60; -2

Z = 4.52, k = 646, p < 0.001*

 

left lateral middle temporal cortex (T2)

-58; -14; -26

Z = 4.20, k = 198, p = 0.048*

 

right anterior mesial frontal

12; 36; 38

Z = 4.12, k = 247, p = 0.020*

 

left anterior inferior frontal gyrus (F3)

-46; 42; 6

Z = 3.66, k = 298, p = 0.009*

GG-CG

right and left mesial frontal pole

4; 62; 10

Z = 5.14, k = 3248, p < 0.001*

 

right lateral orbitofrontal cortex

26; -38; -20

Z = 4.95, k = 357, p = 0.003*

 

right parahippocampal gyrus

38; -16; -26

Z = 4.87, k = 273, p = 0.013*

 

right temporal pole

30; 14; -38

Z = 4.75, k = 574, p < 0.001*

 

right lateral second and third temporal cortex (T2, T3)

60; -22; -16

Z = 4.53, k = 545, p < 0.001*

 

left lateral second and third temporal cortex (T2, T3)

-60; -12; -24

Z = 4.45, k = 383, p = 0.002*

 

left temporal pole

-34; 10; -40

Z = 4.16, k = 393, p = 0.002*

 

right anterior superior and middle frontal gyri (F1, F2)

-14; 26; 52

Z = 4.05, k = 214, p = 0.036*

 

right frontal operculum

52; 14; 6

Z = 3.97, k = 294, p = 0.009*

 

left anterior inferior frontal gyrus (F3)

-42; 28; -2

Z = 3.96, k = 501, p < 0.001*

 

right dorsolateral frontal cortex

42; 36; 30

Z = 3.83, k = 373, p = 0.003*

CC-GG

NS

CC-CG

NS

CG-CC

NS

CG-GG

NS

GG - (GC+CC)

left and right mesial frontal pole

-2; 60; -2

Z = 4.92, k = 2877, p < 0.001*

 

right lateral orbitofrontal cortex

26; -38; -20

 
 

right temporal pole

30; 14; -38

Z = 4.56, k = 215, p = 0.035*

 

left superior and middle frontal gyri (F1, F2)

-16; 20; 50

Z = 4.49, k = 411, p = 0.002*

 

right lateral second and third temporal cortex (T2, T3)

60; -22; -16

Z = 4.43, k = 342, p = 0.004*

 

left lateral middle temporal cortex (T2)

-58; -12; -24

Z = 4.37, k = 321, p = 0.006*

 

left superior frontal gyrus (F1)

-42; 0; 42

Z = 4.22, k = 212, p = 0.037*

 

right frontal operculum

54; 12; 6

Z = 3.88, k = 234, p = 0.025*

 

left anterior inferior frontal gyrus (F3)

-42; 28; -2

Z = 3.87, k = 469, p = 0.001*

 

right dorsolateral frontal cortex

44; 38; 26

Z = 3.82, k = 368, p = 0.003*

(GC+CC) - GG

NS

  1. k is the cluster size expressed in voxels. Only significant findings are shown. NS: no significant.