Kinetic parameter | Amino acid | Children with ADHD (n = 14) | Controls (n = 13) | p-value |
---|
V
max
|
Tyrosine
| 15.1 (11.5-25.4) | 15.5 (7.8-21.5) | 0.617 |
 |
Tryptophan
| 1.5 (1.1-3.0) | 2.0 (1.3-4.7) | 0.039* |
 |
Alanine
| 42.8 (36.3-64.9) | 32.0 (22.7-63.4) | 0.031* |
K
m
|
Tyrosine
| 20.0 (6.3) | 18.8 (5.5) | 0.645 |
 |
Tryptophan
| 13.6 (4.7) | 21.1 (8.2) | 0.010** |
 |
Alanine
| 125.7 (41.2) | 100.7 (30.1) | 0.086 |
-
The results are presented as median (range) for V
max
values and as mean (standard deviation) for K
m
values. ADHD, indicates Attention Deficit/Hyperactivity Disorder,
V
max
, indicates maximal transport capacity (nmol/min/mg protein) and
K
m
, indicates affinity of binding sites for a specific amino acid (μmol/l). *Statistically significant (p ≤ 0.05) **Statistically significant (p ≤ 0.01)