Figure 4From: Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male ratsThe IAA treatment induces hyperactivity of HPA axis in female but not male rats. (A) Crf mRNA expression in hypothalamus is increased in female rats with IAA-induced gastritis. (B) Gr mRNA expression in hypothalamus is reduced in female rats with IAA-induced gastritis. (C) Plasma levels of CORT are decreased in female rats with IAA-induced gastritis. The hypothalamic expressions of corticotropin-releasing factor (CRF) and glucocorticoid receptor (GR), and plasma levels of corticosterone (CORT) were used to assess the HPA axis activity. IAA, iodoacetamide. Values are means ± S.E.M of six rats. *p < 0.05 was significantly different from control group of the same gender. +p < 0.05 was significantly different from male control group.Back to article page