Table 2 Genotype and Allele frequencies of TPH2 gene polymorphisms between children with TD and normal controls
Polymorphisms | Number and frequency (%) | χ 2 | P a | OR [95% CI] | |
|---|---|---|---|---|---|
Normal controls | TD children | ||||
TPH2 rs4565946 | 125 | 149 | |||
CC | 65 (52.00) | 78 (52.35) | 1.00 | ||
CT | 53 (42.40) | 48 (32.21)` | 1.168 | 0.28 | 0.755 [0.453–1.258] |
TT | 7 (5.60) | 23 (15.44) | 4.994 | 0.025 | 2.738 [1.105–6.788] |
CC + CT | 118 (94.40) | 126 (84.56) | 1.00 | ||
TT | 7 (5.60) | 23 (15.44) | 6.745 | 0.009 | 3.077 [1.273–7.437] |
C | 183 (73.20) | 204 (68.46) | 1.00 | ||
T | 67 (26.80) | 94 (31.54) | 1.474 | 0.225 | 1.259 [0.868–1.825] |
TPH2 rs4570625 | 125 | 149 | |||
TT | 44 (35.20) | 37 (24.83) | 1.00 | ||
GT | 57 (45.60) | 75 (50.34) | 2.498 | 0.114 | 1.565 [0.897–2.730] |
GG | 24 (19.20) | 37 (24.83) | 3.127 | 0.077 | 1.833 [0.934–3.599] |
TT + GT | 101 (80.80) | 112 (75.17) | 1.00 | ||
GG | 24 (19.20) | 37 (24.83) | 1.246 | 0.264 | 1.390 [0.779–2.483] |
T | 145 (58.00) | 149 (50.00) | 1.00 | ||
G | 105 (42.00) | 149 (50.00) | 3.499 | 0.061 | 1.381 [0.984–1.937] |