From: DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol
 | Main study | Current study | P values |
---|---|---|---|
n = 112 | N = 267 | ||
Age, mean (SD) | 44.1 (7.7) | 45.1 (7.1) | 0.66 |
Sex, no (%) | Â | Â | 0.72 |
 Male | 67 (60) | 173 (65) |  |
 Female | 45 (40) | 94 (34) |  |
Education no (%) | Â | Â | 0.24 |
 8th grade or less | 13 (12) | 19 (7) |  |
 High school diploma | 73 (65) | 190 (69) |  |
 Some college | 26 (23) | 57 (24) |  |
Race/ethnicity no (%) | Â | Â | 0.26 |
 Caucasian | 17 (15) | 21 (8) |  |
 African–American | 80 (72) | 203 (76) |  |
 Hispanic | 15 (13) | 43 (16) |  |
Alcohol use, mean (SD) | |||
 Number of standard drinks (past 90 days) | 100 (50.1) | 190 (100.1) | 0.10 |
 Lifetime | 22 (10.5) | 23.8 (10.9) | 0.24 |
 AUDIT score | 14 (7.5) | 16 (8.0) | 0.09 |
Other drugs, mean (SD) | |||
 Number of times cocaine use (past 90 days) | 23.5 (16.8) | 33.5 (19.8) | 0.25 |
 Number of times marijuana use (past 90 days) | 19.3 (12.5) | 25.6 (20.9) | 0.63 |
HIV characteristics, mean (SD) | |||
 CD4 count | 412.9 (318.4) | 441.4 (286.9) | 0.73 |
Viral load no (%) | Â | Â | 0.16 |
 Undetectable | 45 (40) | 128 (48) |  |
 50–10,000 | 39 (35) | 80 (30) |  |
 10,001–30,000 | 8 (7) | 29 (11) |  |
 30,000 or more | 20 (18) | 29 (11) |  |
 Taking ART | 76 (68) | 216 (81) | 0.84 |
Cognitive measures, mean (SD) | |||
 Executive skills T-scores | 50.1 (9.0) | 45.2 (10.9) | 0.93 |
 Memory skills (learning) T-scores | 45.9 (10.1) | 48.2 (9.1) | 0.18 |
 Memory skills (recall) T-scores | 48.1 (9.8) | 40.0 (10.5) | 0.11 |
 Cognitive flexibility T-scores | 40.4 (10.4) | 45.7 (10.8) | 0.09 |
 Visual memory T-scores | 47.9 (11.9) | 43.1 (13.8) | 0.09 |