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Fig. 2 | Behavioral and Brain Functions

Fig. 2

From: Thrombin-induced microglial activation impairs hippocampal neurogenesis and spatial memory ability in mice

Fig. 2

The effect of anti-inflammation drugs on thrombin induced microglia proliferation in the DG of hippocampus. a The CD68 immuno-staining in sham mice. c The CD68 staining of microglia cells in the DG in ICH group. e The CD68 immuno-staining in the “thrombin + hirudin” group. g The CD68 staining in “thrombin + indo” group. b, d, f, h DAPI staining of a, c, e, g. i Compared with the CD68 pixel abundance of sham, the injection of thrombin in the striatum leads to increased microglia cells in the hippocampus. Hirudin (the specific inhibitor of thrombin) significantly decreased the microglia density as compared with ICH group. Indo (the anti-inflammation drug) also decreased the CD68 pixel abundance in the hippocampus. n = 10 mice/group. **p < 0.01, compared with sham, ##p < 0.01, compared with ICH group, blue DAPI; red CD68; scale bar 50 µm

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Behavioral and Brain Functions

ISSN: 1744-9081

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