Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population

Yang, Yongfeng; Yu, Hongyan; Li, Wenqiang; Liu, Bing; Zhang, Hongxing; Ding, Shuang; Lu, Yanli; Jiang, Tianzi; Lv, Luxian

doi:10.1186/s12993-017-0133-4

Table 3 Association analysis between five factors of PANSS and five SNPs of CDNF2 in patients with SZ

From: Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population

SNP	Genotype	Total PANSS		Positive		Negative		Depression/anxiety		Cognition		Excitement/hostility
SNP	Genotype	Stage 1	Stage 2	Stage 1	Stage 2	Stage 1	Stage 2	Stage 1	Stage 2	Stage 1	Stage 2	Stage 1	Stage 2
rs2577075	AA	80.46 ± 18.15	86.36 ± 8.49	20.22 ± 6.60	22.63 ± 5.53	17.02 ± 5.45	19.70 ± 3.39	14.39 ± 2.97	14.51 ± 2.28	16.73 ± 5.62	17.21 ± 3.93*	7.44 ± 3.53	6.93 ± 2.99
	AG	81.24 ± 20.65	84.67 ± 11.44	20.49 ± 8.02	22.17 ± 5.95	17.76 ± 5.73	19.81 ± 3.25	13.70 ± 3.53	14.35 ± 2.75	16.67 ± 5.22	15.85 ± 3.71*	7.58 ± 4.03	7.22 ± 3.03
	GG	84.45 ± 19.93	81.79 ± 10.21	19.83 ± 7.23	21. 09 ± 6.60	19.03 ± 5.53	18.74 ± 2.70	14.85 ± 3.39	13.35 ± 2.23	17.90 ± 5.20	14.87 ± 3.14*	7.33 ± 3.96	7.43 ± 3.13
rs2577074	AA	84.45 ± 19.93	83.16 ± 9.36	19.83 ± 7.23	22.14 ± 5.56	19.03 ± 5.53	19.30 ± 2.79	14.85 ± 3.39	14.11 ± 2.63	17.90 ± 5.20	15.95 ± 4.08	7.33 ± 3.96	6.50 ± 2.66
	AG	81.24 ± 20.65	85.75 ± 10.34	20.49 ± 8.02	21.99 ± 6.14	17.76 ± 5.73	19.59 ± 3.34	13.70 ± 3.53	14.51 ± 2.38	16.67 ± 5.22	16.17 ± 3.75	7.58 ± 4.03	7.62 ± 3.05
	GG	80.46 ± 18.15	84.48 ± 12.39	20.22 ± 6.60	22.54 ± 6.09	17.02 ± 5.45	20.17 ± 3.62	14.39 ± 2.97	13.63 ± 2.83	16.73 ± 5.62	16.21 ± 3.26	7.44 ± 3.53	7.04 ± 3.41
rs2249810	AA	82.33 ± 21.05	87.79 ± 14.62	18.87 ± 7.51	23.07 ± 6.58	18.80 ± 5.80	21.00 ± 4.28	15.03 ± 3.54	13.86 ± 3.03	17.70 ± 5.55	16.57 ± 3.82	6.80 ± 3.89	6.71 ± 3.43
	AG	81.67 ± 20.87	85.00 ± 10.52	20.46 ± 8.01	21.97 ± 6.19	17.85 ± 5.84	19.60 ± 3.03	13.66 ± 3.57	14.38 ± 2.53	16.88 ± 5.35	16.29 ± 3.54	7.68 ± 4.05	7.32 ± 3.19
	GG	81.77 ± 17.73	83.92 ± 9.27	20.74 ± 6.54	21.90 ± 5.56	17.42 ± 5.20	19.27 ± 3.12	14.42 ± 2.88	14.25 ± 2.48	16.74 ± 5.18	16.05 ± 3.92	7.57 ± 3.61	7.17 ± 2.83
rs2118343^a	CC	82.74 ± 19.47	85.00 ± 2.00	21.04 ± 7.30	19.33 ± 0.58	17.71 ± 5.57	20.00 ± 3.46	14.38 ± 3.23	13.33 ± 2.52	17.23 ± 5.47	18.33 ± 3.51	7.43 ± 3.93	8.00 ± 4.00
	CG	80.05 ± 20.86	85.17 ± 10.43	19.03 ± 7.57	21.90 ± 5.72	17.90 ± 5.77	19.35 ± 3.29	13.63 ± 3.58	13.90 ± 2.41	16.63 ± 5.22	16.53 ± 3.45	7.68 ± 3.84	7.60 ± 3.21
	GG	85.43 ± 15.64	84.50 ± 10.63	20.71 ± 8.28	22.32 ± 6.09	20.14 ± 5.18	19.68 ± 3.21	15.71 ± 3.20	14.40 ± 2.61	16.71 ± 4.23	15.86 ± 3.88	6.43 ± 3.82	6.96 ± 2.92
rs6506891	AA	81.07 ± 20.23	84.08 ± 9.28	18.48 ± 7.34	22.06 ± 5.66	18.55 ± 5.74	19.31 ± 3.11	15.14 ± 3.55	14.27 ± 2.46	17.55 ± 5.59	15.95 ± 3.97	6.41 ± 3.33	7.17 ± 2.81
	AT	79.48 ± 20.69	84.84 ± 10.51	19.08 ± 7.65	21.93 ± 6.14	17.69 ± 5.61	19.63 ± 3.01	13.29 ± 3.56	14.34 ± 2.53	16.31 ± 4.84	16.20 ± 3.58	7.85 ± 3.92	7.32 ± 3.17
	TT	82.94 ± 19.02	86.87 ± 14.53	21.39 ± 7.24	23.20 ± 6.36	17.68 ± 5.60	20.67 ± 4.32	14.32 ± 3.15	13.67 ± 3.02	17.10 ± 5.49	16.40 ± 3.74	7.52 ± 3.86	6.53 ± 3.38

* P < 0.05, compared with each other genotype, LSD tests
^aCombine stage 1 and 2 samples: rs2118343 genotypes were significantly associated with negative factor scores

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ISSN: 1744-9081

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