Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

Table 3 SNPs nominally associated with CSF MHPG concentrations in psychotic patients

		Patients with psychosis (n = 74; 45 men, 29 women)			Healthy controls (n = 111; 63 men, 48 women)
MHPG mean (S.D.)		43.3 (9.3) nmol/l			41.7 (8.1) nmol/l
Gene	SNP	MAF(%)	HWE	P	MAF (%)	HWE	P
MAOB (men)	rs5905512	47		0.0004	50		0.479
MAOB (men)	rs1799836	38		0.0008	44		0.483
DDC	rs11575535	4	1.000	0.005	4	1.000	0.126
TPH1	rs4537731	44	0.475	0.007	40	0.047	0.646
DDC	rs6592961	28	0.400	0.008	29	0.104	0.855
TPH1	rs7933505	41	0.148	0.010	41	0.334	0.342
DDC	rs7809758	40	0.811	0.013	38	0.159	0.956
TPH1	rs7122118	43	0.239	0.014	40	0.029	0.821
DBH	rs6271	3	1.000	0.017	5	1.000	0.340
TPH1	rs1799913	42	0.096	0.017	41	0.334	0.342
TPH1	rs684302	42	0.232	0.017	41	0.171	0.397
DDC	rs9942686	21	0.723	0.018	23	1.000	0.189
MAOB (men)	rs6651806	24		0.021	32		0.328
DDC	rs17133853	11	1.000	0.033	9	0.569	0.436
DBH	rs1611115	21	1.000	0.035	14	1.000	0.791
DBH	rs3025388	18	0.445	0.047	18	0.517	0.064
TPH1	rs12292915	44	0.161	0.047	43	0.052	0.066
TPH1	rs211105	31	0.785	0.049	25	0.449	0.033

Minor allele frequencies (MAF), p-values of testing for Hardy–Weinberg equilibrium (HWE) and p-values (P) from multiple linear regressions of single nucleotide polymorphisms (SNPs) nominally associated with 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations in the cerebrospinal fluid of psychotic patients and the corresponding association statistics among healthy controls. MAOA and MAOB are located on chromosome X and the analyses were therefore conducted separately for men and women.

ISSN: 1744-9081