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Table 2 Association between SNPs in SLC6A3 and dyslexia using the additive, dominant, genotype, and the recessive models

From: Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population

 

SNP

Patient

Control

Crude OR (95%CI)

Unadjusted p-value

Adjusted OR (95%CI)

Adjusted p-value

Bonferroni corrected p-value

rs11133762

C Allele

552

629

1

 

1

  

T Allele

386

363

1.222(1.013-1.475)

0.03628

1.232(1.004-1.511)

0.04568

1

CC

158

194

1

 

1

  

CT

236

241

1.2024(0.9121-1.5850)

0.19106664

1.1500(0.8517-1.5527)

0.361697

1

TT

75

61

1.5096(1.0141-2.2474)

0.04246577

1.5575(1.0121-2.3967)

0.043953

1

Dom

  

1.264(0.972-1.645)

0.08041

1.235(0.9291-1.642)

0.1461

1

Rec

  

1.357(0.9429-1.954)

0.1002

1.46(0.9799-2.175)

0.06285

1

rs3863145

G Allele

925

974

1

 

1

  

A Allele

37

44

0.8916(0.5778-1.376)

0.604

0.935(0.5856-1.493)

0.7783

1

GG

445

468

1

 

1

  

AG

35

38

0.9687(0.6011-1.5610)

0.89593367

1.0151(0.6043-1.7051)

0.954917

1

AA

1

3

0.3506(0.0364-3.3758)

0.36433775

0.4064(0.0394-4.1922)

0.449521

1

Dom

  

0.9234(0.5794-1.472)

0.7376

0.9701(0.5851-1.608)

0.9063

1

Rec

  

0.3514(0.03643-3.39)

0.3658

0.4136(0.0402-4.256)

0.458

1

rs40184

C Allele

734

796

1

 

1

  

T Allele

232

218

1.151(0.9343-1.417)

0.1867

1.127(0.9-1.411)

0.2976

1

CC

281

314

1

 

1

  

CT

172

168

1.1440(0.8763-1.4937)

0.32260995

1.0956(0.8214-1.4613)

0.53434

1

TT

30

25

1.3409(0.7701-2.3350)

0.29988039

1.3203(0.7261-2.4007)

0.362334

1

Dom

  

1.17(0.9067-1.509)

0.228

1.128(0.8567-1.485)

0.3909

1

Rec

  

1.277(0.7396-2.204)

0.3804

1.306(0.7249-2.355)

0.3738

1

rs6869645

C Allele

939

987

1

 

1

  

T Allele

27

33

0.8604(0.5137-1.441)

0.5677

0.8694(0.4988-1.515)

0.6214

1

CC

456

478

1

 

1

  

CT

27

31

0.9130(0.5365-1.5539)

0.73717584

0.9431(0.5296-1.6794)

0.842233

1

TT

0

1

NA

 

NA

  

Dom

  

0.8845(0.5216-1.5)

0.6486

0.9032(0.5099-1.6)

0.7273

1

Rec

  

NA

 

NA

  

rs40358

A Allele

617

643

1

 

1

  

C Allele

347

375

0.9625(0.7976-1.161)

0.6899

0.9412(0.768-1.154)

0.5595

1

AA

190

199

1

 

1

  

AC

237

245

1.01329(0.7756-1.3235)

0.92355677

0.9603(0.7183-1.2838)

0.784396

1

CC

55

65

0.8862(0.5879-1.3360)

0.56412977

0.8738(0.5617-1.3593)

0.549582

1

Dom

  

0.9866(0.7644-1.273)

0.9172

0.945(0.7171-1.245)

0.6877

1

Rec

  

0.8798(0.6-1.29)

0.5123

0.8838(0.5843-1.337)

0.5587

1

rs10052016

A Allele

861

923

1

 

1

  

G Allele

101

93

1.167(0.8654-1.575)

0.3109

1.098(0.7937-1.52)

0.5712

1

AA

385

418

1

 

1

  

AG

91

87

1.1356(0.8206-1.5715)

0.44286861

1.0895(0.7663-1.5492)

0.632995

1

GG

5

3

1.8095(0.4297-7.6209)

0.41883352

1.3168(0.2851-6.0832)

0.724443

1

Dom

  

1.158(0.8417-1.594)

0.3674

1.098(0.7764-1.552)

0.5977

1

 

Rec

  

1.768(0.4203-7.439)

0.4369

1.297(0.2802-6.001)

0.7396

1

rs403636

C Allele

645

677

1

 

1

  

A Allele

319

341

0.9808(0.8089-1.189)

0.8435

0.9492(0.7711-1.168)

0.6232

1

CC

208

220

1

 

1

  

AC

229

237

1.0220(0.7860-1.3288)

0.87099199

1.0459(0.7870-1.3900)

0.756883

1

AA

45

52

0.9153(0.5884-1.4238)

0.6946183

0.7948(0.4921-1.2836)

0.347614

1

Dom

  

1.003(0.7798-1.29)

0.9826

0.9992(0.7614-1.311)

0.9952

1

Rec

  

0.905(0.5946-1.377)

0.6413

0.7838(0.4989-1.232)

0.2907

1

rs2937639

T Allele

816

878

1

 

1

  

C Allele

150

142

1.136(0.8864-1.456)

0.3137

1.128(0.8626-1.476)

0.3783

1

TT

344

379

1

 

1

  

CT

128

120

1.1752(0.8805-1.5684)

0.27303583

1.1803(0.8642-1.6120)

0.297244

1

CC

11

11

1.1017(0.4717-2.5736)

0.82287421

1.0280(0.4145-2.5496)

0.952512

1

Dom

  

1.169(0.8837-1.546)

0.2739

1.169(0.8636-1.582)

0.3123

1

Rec

  

1.057(0.4541-2.462)

0.8974

0.9771(0.3924-2.433)

0.9603

1

rs3756450

A Allele

506

535

1

 

1

  

G Allele

454

485

0.989(0.8238-1.187)

0.9055

1.018(0.8355-1.24)

0.8615

1

AA

124

133

1

 

1

  

AG

258

269

1.0287(0.7633-1.3864)

0.85244842

1.0910(0.7906-1.5055)

0.596073

1

GG

98

108

0.9733(0.6743-1.4047)

0.8849171

1.0310(0.6914-1.5373)

0.881023

1

Dom

  

1.013(0.7622-1.346)

0.9299

1.073(0.7889-1.458)

0.6547

1

Rec

  

0.9549(0.7023-1.298)

0.7685

0.9685(0.6952-1.349)

0.8497

1

rs2550946

A Allele

823

886

1

 

1

  

G Allele

143

134

1.148(0.8909-1.479)

0.2859

1.141(0.8671-1.501)

0.3463

1

AA

350

386

1

 

1

  

AG

123

114

1.1899(0.8877-1.5951)

0.24476629

1.2021(0.8760-1.6495)

0.254198

1

GG

10

10

1.1029(0.4536-2.6813)

0.82898896

1.0040(0.3872-2.6035)

0.99349

1

Dom

  

1.183(0.8902-1.572)

0.2468

1.186(0.8724-1.613)

0.2761

1

Rec

  

1.057(0.4361-2.563)

0.9022

0.9507(0.3652-2.475)

0.9176

1

rs12652860

C Allele

595

615

1

 

1

  

A Allele

371

403

0.9467(0.7832-1.144)

0.5712

0.9343(0.761-1.147)

0.5166

1

CC

173

174

1

 

1

  

AC

249

267

0.9380(0.7144-1.2314)

0.64476562

0.9233(0.6859-1.2428)

0.598692

1

AA

61

68

0.9022(0.6020-1.3523)

0.6183072

0.8904(0.5778-1.3720)

0.598766

1

Dom

  

0.9307(0.7169-1.208)

0.5898

0.9163(0.691-1.215)

0.544

1

Rec

  

0.9374(0.6472-1.358)

0.7326

0.9203(0.6162-1.374)

0.6849

1

rs12654851

G Allele

536

549

1

 

1

  

T Allele

430

471

0.9285(0.771-1.118)

0.4343

0.9315(0.7625-1.138)

0.4869

1

GG

137

136

1

 

1

  

GT

262

277

0.9389(0.7017-1.2564)

0.67158199

0.9964(0.7282-1.3633)

0.981816

1

TT

84

97

0.8597(0.5900-1.2525)

0.43094129

0.8456(0.5610-1.2747)

0.423275

1

Dom

  

0.9184(0.695-1.214)

0.5493

0.9584(0.7095-1.295)

0.782

1

 

Rec

  

0.8964(0.649-1.238)

0.5066

0.8546(0.6038-1.21)

0.3754

1

  1. Bold data: adjusted p value < 0.05.
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