Figure 1

Nociceptive behavior in IB4-SAP and SAP treated SCC mice. A. Mechanical thresholds were decreased from baseline following SCC inoculation in both treatment groups (P < 0.001 for baseline vs. week 2 and week 4 in the IB4-SAP and SAP groups). IB4-SAP (N = 8) and SAP (N = 8) treated mice had similar mechanical thresholds at baseline and at post inoculation week 2. However, IB4-SAP significantly reduced SCC-induced mechanical allodynia compared to SAP treated mice at week 4 post inoculation (*, P < 0.05). While no difference in mechanical thresholds was found in IB4-SAP group between week 2 and week 4, mechanical thresholds were significantly reduced in SAP mice from week 2 to week 4 (#, P < 0.001). B. Thermal latency was decreased from baseline following SCC inoculation (P < 0.001 for baseline vs. week 2 and week 4 in the IB4-SAP and SAP groups). IB4-SAP and SAP treated mice had similar thermal latency at baseline and at week 2 post inoculation. IB4-SAP treatment significantly increased thermal hyperalgesia compared to SAP treated mice at week 4 post inoculation (*, P < 0.05).