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Table 1 Distributions of allele frequencies of APOE and STH gene variations in European-American subjects

From: Variation at APOE and STH loci and Alzheimer's disease

  APOE alleles Exact p-values STH alleles Exact p-values  
  ε 2 ε 3 ε 4 Total ε 2 ε 3 ε 4 Total Q R Total   
  f n f n f n 2N      f n f n 2N   
AD 0.024 17 0.617 443 0.359 258 718 0.001 6.0*10-12 2.4*10-18 1.2*10-18 0.767 439 0.233 133 572 0.345 1
EOAD 0.017 6 0.590 203 0.392 135 344 0.002 4.7*10-11 6.8*10-17 2.5*10-17 0.771 216 0.229 64 280 0.506 2
LOAD 0.027 10 0.644 237 0.329 121 368 0.022 3.6*10-7 3.1*10-11 5.5*10-11 0.762 218 0.238 68 286 0.348 2
FH+ 0.014 5 0.590 204 0.396 137 346 6.8*10-4 4.9*10-11 2.1*10-16 2.3*10-17 0.737 205 0.263 73 278 0.094 2
FH- 0.030 11 0.641 232 0.329 119 362 0.051 2.2*10-7 4.1*10-11 1.1*10-10 0.796 226 0.204 58 284 1.000 2
Male 0.032 9 0.635 179 0.333 94 282 0.093 3.9*10-5 1.7*10-7 3.9*10-7 0.738 155 0.262 55 210 0.145 3
Female 0.018 8 0.606 264 0.376 164 436 0.008 7.0*10-8 9.8*10-12 4.9*10-12 0.785 284 0.215 78 362 1.000 3
Controls 0.061 30 0.801 394 0.138 68 492      0.794 313 0.206 81 394   
Male 0.065 15 0.800 184 0.135 31 230      0.805 140 0.195 34 174   
Female 0.057 15 0.802 210 0.141 37 262      0.786 173 0.214 47 220   
  1. f, frequency; n, number of alleles; N, number of individuals; 2N, number of chromosomes; AD, Alzheimer's disease; EOAD, early-onset AD (≤70yrs); LOAD, late-onset AD (>70yrs); Controls, the total controls combining two subgroups through two different diagnostic evaluations. The numbers in last column denote: 1. Comparing overall AD with controls (α was set at 0.017 for each APOE allele comparison); 2. Comparing EOAD, LOAD, FH+AD and FH-AD with controls respectively (α was set at 0.003 for each APOE allele comparison); 3. Comparing male AD with male controls and female AD with female controls (α was set at 0.003 for each APOE allele comparison).