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Table 3 Interpretation of PPVs and LRs+ of APOE alleles and genotypes

From: Variation at APOE and STH loci and Alzheimer's disease

allele/genotype PPV [ (AD|ε)] LR+ LR range1 Significance for diagnosis
    > 10 greatly increasing risk for AD
    5~ 10 moderately increasing risk for AD
ε 4/ε 4 39.90% 3.76 2~ 5 small increase in risk for AD
ε 4 31.50% 2.60   
ε 3/ε 4 28.80% 2.29   
    1~ 2 minimally increasing risk for AD
  15.00% (population prevalence)   1 no change in risk for AD
ε 3 12.00% 0.77 0.5~ 1 minimally decreasing risk for AD
ε 2/ε 4 10.82% 0.69   
ε 3/ε 3 9.40% 0.59   
ε 2 6.50% 0.39 0.2~ 0.5 small decrease in risk for AD
ε 2/ε 3 5.70% 0.34   
    0.1~ 0.2 moderately decreasing risk for AD
    < 0.1 greatly decreasing risk for AD
  1. PPV, estimated positive predictive value; LR+, positive likelihood ratios.
  2. 1Reference to [39].