Table 1 Mean (+ SD) novelty seeking and harm avoidance scores dependent on an individual's COMT and DRD2 genotype
DRD2 | COMT | N | Mean (± SD) |
|---|---|---|---|
Clinical Sample 1 | |||
Novelty seeking | |||
A1 absent | Val absent | 19 | 56.2 ± 14.0 |
Val present | 69 | 51.8 ± 18.3 | |
A1 present | Val absent | 19 | 47.4 ± 13.6 |
Val present | 39 | 51.0 ± 15.1 | |
DRD2 main effect | F (1,142) = 2.38, p = 0.125 | ||
COMT main effect | F (1,142) = 0.015, p = 0.901 | ||
DRD2 × COMT | F (1,142) = 1.62, p = 0.206 | ||
Harm avoidance | |||
A1 absent | Val absent | 19 | 70.8 ± 15.9 |
Val present | 69 | 67.0 ± 21.0 | |
A1 present | Val absent | 19 | 66.9 ± 23.4 |
Val present | 39 | 66.3 ± 19.8 | |
DRD2 main effect | F (1,142) = 0.356, p = 0.552 | ||
COMT main effect | F (1,142) = 0.319, p = 0.573 | ||
DRD2 × COMT | F (1,142) = 0.165, p = 0.685 | ||
Clinical Sample 2 | |||
Novelty seeking | |||
A1 absent | Val absent | 16 | 48.3 ± 18.5 |
Val present | 62 | 47.9 ± 15.9 | |
A1 present | Val absent | 14 | 46.4 ± 12.5 |
Val present | 54 | 47.9 ± 14.0 | |
DRD2 main effect | F (1,142) = 0.087, p = 0.769 | ||
COMT main effect | F (1,142) = 0.027, p = 0.870 | ||
DRD2 × COMT | F (1,142) = 0.088, p = 0.767 | ||
Harm avoidance | |||
A1 absent | Val absent | 16 | 70.7 ± 18.1 |
Val present | 62 | 72.3 ± 15.9 | |
A1 present | Val absent | 14 | 73.1 ± 17.5 |
Val present | 54 | 69.3 ± 22.1 | |
DRD2 main effect | F (1,142) = 0.008, p = 0.928 | ||
COMT main effect | F (1,142) = 0.082, p = 0.775 | ||
DRD2 × COMT | F (1,142) = 0.489, p = 0.485 |