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Table 3 Mediating effects of gender, age, and IQ on the relation between the endophenotypic construct and phenotype

From: Relationship between endophenotype and phenotype in ADHD

mediator

endophenotype → mediator

mediator → phenotype

endophenotype → phenotype

test of mediation: z = a × b/√(b2s a 2 + a2s b 2)

endophenotype → phenotype corrected for mediation

 

a

s a

p

b

s b

p

c

s c

p

z

p

c

s c

p

gender

              

first-borns

-0.129

.026

<.001

-0.319

.108

.003

7.215

.657

<.001

2.538

.01

5.963

0.629

<.001

second-borns

-0.020

.028

.47

-0.285

.113

.01

2.390

.771

.002

0.687

.49

2.148

0.697

.002

age

              

first-borns

-1.724

.117

<.001

-1.383

.271

<.001

7.215

.657

<.001

4.822

<.001

8.041

0.846

<.001

second-borns

-2.130

.102

<.001

0.889

.275

.001

2.390

.771

.002

-3.195

.001

10.150

1.044

<.001

IQ

              

first-borns

-2.264

.608

<.001

-0.255

.067

<.001

7.215

.657

<.001

2.662

.008

6.916

0.667

<.001

second-borns

-1.222

.633

.05

-0.328

.066

<.001

2.390

.771

.002

1.799

.07

2.012

0.752

.008

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Behavioral and Brain Functions

ISSN: 1744-9081

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