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Table 3 Mediating effects of gender, age, and IQ on the relation between the endophenotypic construct and phenotype

From: Relationship between endophenotype and phenotype in ADHD

mediator endophenotype → mediator mediator → phenotype endophenotype → phenotype test of mediation: z = a × b/√(b2s a 2 + a2s b 2) endophenotype → phenotype corrected for mediation
  a s a p b s b p c s c p z p c s c p
gender               
first-borns -0.129 .026 <.001 -0.319 .108 .003 7.215 .657 <.001 2.538 .01 5.963 0.629 <.001
second-borns -0.020 .028 .47 -0.285 .113 .01 2.390 .771 .002 0.687 .49 2.148 0.697 .002
age               
first-borns -1.724 .117 <.001 -1.383 .271 <.001 7.215 .657 <.001 4.822 <.001 8.041 0.846 <.001
second-borns -2.130 .102 <.001 0.889 .275 .001 2.390 .771 .002 -3.195 .001 10.150 1.044 <.001
IQ               
first-borns -2.264 .608 <.001 -0.255 .067 <.001 7.215 .657 <.001 2.662 .008 6.916 0.667 <.001
second-borns -1.222 .633 .05 -0.328 .066 <.001 2.390 .771 .002 1.799 .07 2.012 0.752 .008