Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level

Table 2 Haplotypes based on best pairs (unweighted) UNADJUSTED

		Rare (< 5%)		ATAA		GTGA
Response	N	b	se	b	se	b	se	LR P-value
IQ (RPM)	1703	-0.626	(0.792)	-0.366	(0.332)	0.265	(0.527)	0.50
SPQ total score	1211	1.214	(1.279)	0.683	(0.539)	0.424	(0.881)	0.55
SPQ cognitive/perceptual factor	1211	0.003	(0.012)	0.003	(0.005)	-0.001	(0.008)	0.91
SPQ negative factor	1211	0.012	(0.013)	0.011*	(0.005)	0.020*	(0.009)	0.059
SPQ disorganization factor	1211	0.026	(0.021)	0.012	(0.009)	0.004	(0.014)	0.42
SPQ paranoid factor	1211	0.006	(0.019)	0.001	(0.008)	-0.007	(0.013)	0.92
d'-S2B (spatial working memory)	1656	-0.047	(0.091)	-0.015	(0.039)	0.146*	(0.063)	0.073
d'-V2B (verbal working memory)	1583	0.017	(0.077)	-0.028	(0.034)	0.015	(0.053)	0.77
Antisaccade error rate	1835	-0.023	(0.018)	0.013	(0.008)	0.013	(0.012)	0.10

The reference haplotype is GGGG
Shown are the coefficients of a regression model/copy of the corresponding haplotype. b, coefficient, expressing change in the response variable/haplotype copy; SE, standard error of the coefficient b; LR p value, p value for a likelihood ratio test against a constant-only model;
* significantly different (p < 0.05) from the reference haplotype GGGG (the most common in the population).

ISSN: 1744-9081