Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level

Table 5 Haplotypes weighting for the probability of each haplotype ADJUSTED for age, IQ and interaction

		Rare (< 5%)		ATAA		GTGA
Response	N	b	se	b	se	b	se	LR P-value
SPQ total score	1203	0.741	(1.290)	0.510	(0.543)	0.517	(0.895)	0.77
SPQ cognitive/perceptual factor	1203	-0.001	(0.012)	0.001	(0.005)	-0.001	(0.008)	0.99
SPQ negative factor	1203	0.005	(0.013)	0.009	(0.005)	0.021*	(0.009)	0.071
SPQ disorganization factor	1203	0.018	(0.021)	0.009	(0.009)	0.005	(0.015)	0.67
SPQ paranoid factor	1203	0.003	(0.019)	-0.001	(0.008)	-0.007	(0.014)	0.95
d'-S2B (spatial working memory)	1462	0.124	(0.085)	0.018	(0.036)	0.135*	(0.059)	0.077
d'-V2B (verbal working memory)	1394	0.053	(0.073)	-0.004	(0.032)	0.017	(0.051)	0.87
Antisaccade error rate	1622	-0.025	(0.019)	0.008	(0.008)	0.002	(0.013)	0.35

The reference haplotype is GGGG. Shown are the coefficients of a regression model/copy of the corresponding haplotype. b, coefficient, expressing change in the response variable/haplotype copy; SE, standard error of the coefficient b; LR p value, p value for a likelihood ratio test against a constant-only model;
* significantly different (p < 0.05) from the reference haplotype GGGG (the most common in the population).

ISSN: 1744-9081