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Figure 3 | Behavioral and Brain Functions

Figure 3

From: Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice

Figure 3

Acquisition, extinction and reinstatement of 2.5 mg/kg MDMA- and WIN-induced CPP. Acquisition, extinction and reinstatement of MDMA- and WIN-induced CPP in four groups of animals: SAL, animals receiving saline in both compartments (n = 10); MDMA 2.5, animals receiving 2.5 mg/kg of MDMA in the drug-paired compartment (n = 10); MDMA 2.5 + WIN 0.5 and MDMA 2.5 + WIN 0.1 animals receiving 0.5 or 0.1 mg/kg of WIN plus 2.5 mg/kg of MDMA in the drug-paired compartment (n = 11). The bars represent the mean (± SEM) time spent in the drug-paired compartment before conditioning sessions (white bars), after conditioning sessions (blue bars), in the last extinction session (light blue bars) and in the reinstatement test (dark blue bars). * p < 0.05; ** p < 0.02 significant difference in the time spent in pre-conditioning vs. post-conditioning sessions or reinstatement tests.

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