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Figure 5 | Behavioral and Brain Functions

Figure 5

From: Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice

Figure 5

Reinstatement of MDMA-induced CPP by priming injections of WIN. Reinstatement of MDMA-induced CPP by priming injections of WIN in six groups of animals (n = 10): Sal-RWIN 0.5 and Sal-RWIN 0.1, animals conditioned with saline in the drug-paired compartment and receiving a priming injection of 0.5 or 0.1 mg/kg of WIN; MDMA 2.5-RWIN 0.5 and MDMA 2.5-RWIN 0.1, animals conditioned with 2.5 mg/kg of MDMA in the drug-paired compartment and receiving a priming injection of 0.5 or 0.1 mg/kg of WIN.; MDMA 5-RWIN 0.5 and MDMA 5-RWIN 0.1, animals conditioned with 5 mg/kg of MDMA in the drug-paired compartment and receiving a priming injection of 0.5 and 0.1 mg/kg of WIN. The bars represent the mean (± SEM) time spent in the drug-paired compartment before conditioning sessions (white bars), after conditioning sessions (pink bars), in the last extinction session (light pink bars) and in the reinstatement test (dark pink bars). * = p < 0.05, ** = p < 0.02 significant difference in the time spent in pre-conditioning vs. post-conditioning sessions or reinstatement tests.

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