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Table 2 Genetic analyses of the dopaminergic polymorphisms in the US young adult sample

From: Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients

  

BPD trait (N = 99)

APD trait (N = 98)

  

0 or 1

2 or more

 

0 or 1

2 or more

 
  

N

(%)

N

(%)

p

N

(%)

N

(%)

p

COMT

Met/Met

12

(15.2)

4

(20.0)

 

12

(16.7)

4

(15.4)

 
 

Met/Val

38

(48.1)

7

(35.0)

0.572

30

(41.7)

14

(53.8)

0.539

 

Val/Val

29

(36.7)

9

(45.0)

 

30

(41.7)

8

(30.8)

 

DAT1

9/9

9

(11.5)

1

(5.0)

 

8

(11.3)

2

(7.7)

 

40 bp

one 9

25

(32.1)

7

(35.0)

0.689

25

(35.2)

7

(26.9)

0.576

VNTR

no 9

44

(56.4)

12

(60.0)

 

38

(53.5)

17

(65.4)

 

DRD2

B1/B1

0

(0.0)

1

(5.0)

 

0

(0.0)

1

(3.8)

 

TaqIB

B1/B2

15

(19.5)

11

(55.0)

0.001

17

(24.3)

9

(34.6)

0.137

 

B2/B2

62

(80.5)

8

(40.0)

 

53

(75.7)

16

(61.5)

 
 

B1+

15

(19.5)

12

(60.0)

 

17

(24.3)

10

(38.5)

 
 

B1-

62

(80.5)

8

(40.0)

0.0003

53

(75.7)

16

(61.5)

0.170

TaqID

C/C

22

(28.6)

5

(25.0)

 

21

(30.0)

6

(23.1)

 
 

C/T

32

(41.6)

12

(60.0)

0.276

27

(38.6)

17

(65.4)

0.046

 

T/T

23

(29.9)

3

(15.0)

 

22

(31.4)

3

(11.5)

 

TaqIA

A1/A1

3

(3.8)

3

(15.0)

 

4

(5.6)

2

(7.7)

 
 

A1/A2

26

(32.9)

12

(60.0)

0.005

25

(34.7)

13

(50.0)

 
 

A2/A2

50

(63.3)

5

(25.0)

 

43

(59.7)

11

(42.3)

0.310

 

A1+

29

(36.7)

15

(75.0)

 

29

(40.3)

15

(57.7)

 
 

A1-

50

(63.3)

5

(25.0)

0.002

43

(59.7)

11

(42.3)

0.126

DRD4

1/1

4

(5.1)

1

(5.0)

 

3

(4.2)

2

(7.7)

 

120 bp

1/2

26

(32.9)

9

(45.0)

0.592

26

(36.1)

9

(34.6)

0.782

dup

2/2

49

(62.0)

10

(50.0)

 

43

(59.7)

15

(57.7)

 

-616

C/C

14

(17.7)

9

(45.0)

 

14

(19.4)

9

(34.6)

 
 

C/G

41

(51.9)

9

(45.0)

0.020

39

(54.2)

11

(42.3)

0.289

 

G/G

24

(30.4)

2

(10.0)

 

19

(26.4)

6

(23.1)

 
 

C/C

14

(17.7)

9

(45.0)

 

14

(19.4)

9

(34.6)

 
 

C/G + G/G

65

(82.3)

11

(55.0)

0.010

58

(80.6)

17

(65.4)

0.118

-521

C/C

10

(12.7)

3

(15.0)

 

11

(15.3)

2

(7.7)

 
 

C/T

46

(58.2)

6

(30.0)

0.061

42

(58.3)

10

(38.5)

0.038

 

T/T

23

(29.1)

11

(55.0)

 

19

(26.4)

14

(53.8)

 
 

C/C + C/T

56

(70.9)

9

(45.0)

 

53

(73.6)

12

(46.2)

 
 

T/T

23

(29.1)

11

(55.0)

0.029

19

(26.4)

14

(53.8)

0.011

48 bp

7/7

2

(2.5)

2

(10.0)

 

3

(4.2)

1

(3.8)

 

VNTR

one 7

20

(25.3)

5

(25.0)

0.314

17

(23.6)

8

(30.8)

0.773

 

no 7

57

(72.2)

13

(65.0)

 

52

(72.2)

17

(65.4)

 
  1. The at-risk population of young adults was divided by the cut-off rate of 2 symptoms of borderline personality disorder (BPD) and 2 symptoms of antisocial personality disorder (APD). For the VNTRs, genotype grouping was based on the number of DAT1 40 bp VNTR 9-repeat alleles and DRD4 48 bp VNTR 7-repeat alleles. For the DAT1 VNTR, one DNA sample, for the DRD2 TaqIB and TaqID SNPs, two DNA samples did not give genotype result (total sample size therefore was 98 or 97 in BPD and 97 or 96 in APD, respectively).
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Behavioral and Brain Functions

ISSN: 1744-9081

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