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Table 2 Genetic analyses of the dopaminergic polymorphisms in the US young adult sample

From: Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients

   BPD trait (N = 99) APD trait (N = 98)
   0 or 1 2 or more   0 or 1 2 or more  
   N (%) N (%) p N (%) N (%) p
COMT Met/Met 12 (15.2) 4 (20.0)   12 (16.7) 4 (15.4)  
  Met/Val 38 (48.1) 7 (35.0) 0.572 30 (41.7) 14 (53.8) 0.539
  Val/Val 29 (36.7) 9 (45.0)   30 (41.7) 8 (30.8)  
DAT1 9/9 9 (11.5) 1 (5.0)   8 (11.3) 2 (7.7)  
40 bp one 9 25 (32.1) 7 (35.0) 0.689 25 (35.2) 7 (26.9) 0.576
VNTR no 9 44 (56.4) 12 (60.0)   38 (53.5) 17 (65.4)  
DRD2 B1/B1 0 (0.0) 1 (5.0)   0 (0.0) 1 (3.8)  
TaqIB B1/B2 15 (19.5) 11 (55.0) 0.001 17 (24.3) 9 (34.6) 0.137
  B2/B2 62 (80.5) 8 (40.0)   53 (75.7) 16 (61.5)  
  B1+ 15 (19.5) 12 (60.0)   17 (24.3) 10 (38.5)  
  B1- 62 (80.5) 8 (40.0) 0.0003 53 (75.7) 16 (61.5) 0.170
TaqID C/C 22 (28.6) 5 (25.0)   21 (30.0) 6 (23.1)  
  C/T 32 (41.6) 12 (60.0) 0.276 27 (38.6) 17 (65.4) 0.046
  T/T 23 (29.9) 3 (15.0)   22 (31.4) 3 (11.5)  
TaqIA A1/A1 3 (3.8) 3 (15.0)   4 (5.6) 2 (7.7)  
  A1/A2 26 (32.9) 12 (60.0) 0.005 25 (34.7) 13 (50.0)  
  A2/A2 50 (63.3) 5 (25.0)   43 (59.7) 11 (42.3) 0.310
  A1+ 29 (36.7) 15 (75.0)   29 (40.3) 15 (57.7)  
  A1- 50 (63.3) 5 (25.0) 0.002 43 (59.7) 11 (42.3) 0.126
DRD4 1/1 4 (5.1) 1 (5.0)   3 (4.2) 2 (7.7)  
120 bp 1/2 26 (32.9) 9 (45.0) 0.592 26 (36.1) 9 (34.6) 0.782
dup 2/2 49 (62.0) 10 (50.0)   43 (59.7) 15 (57.7)  
-616 C/C 14 (17.7) 9 (45.0)   14 (19.4) 9 (34.6)  
  C/G 41 (51.9) 9 (45.0) 0.020 39 (54.2) 11 (42.3) 0.289
  G/G 24 (30.4) 2 (10.0)   19 (26.4) 6 (23.1)  
  C/C 14 (17.7) 9 (45.0)   14 (19.4) 9 (34.6)  
  C/G + G/G 65 (82.3) 11 (55.0) 0.010 58 (80.6) 17 (65.4) 0.118
-521 C/C 10 (12.7) 3 (15.0)   11 (15.3) 2 (7.7)  
  C/T 46 (58.2) 6 (30.0) 0.061 42 (58.3) 10 (38.5) 0.038
  T/T 23 (29.1) 11 (55.0)   19 (26.4) 14 (53.8)  
  C/C + C/T 56 (70.9) 9 (45.0)   53 (73.6) 12 (46.2)  
  T/T 23 (29.1) 11 (55.0) 0.029 19 (26.4) 14 (53.8) 0.011
48 bp 7/7 2 (2.5) 2 (10.0)   3 (4.2) 1 (3.8)  
VNTR one 7 20 (25.3) 5 (25.0) 0.314 17 (23.6) 8 (30.8) 0.773
  no 7 57 (72.2) 13 (65.0)   52 (72.2) 17 (65.4)  
  1. The at-risk population of young adults was divided by the cut-off rate of 2 symptoms of borderline personality disorder (BPD) and 2 symptoms of antisocial personality disorder (APD). For the VNTRs, genotype grouping was based on the number of DAT1 40 bp VNTR 9-repeat alleles and DRD4 48 bp VNTR 7-repeat alleles. For the DAT1 VNTR, one DNA sample, for the DRD2 TaqIB and TaqID SNPs, two DNA samples did not give genotype result (total sample size therefore was 98 or 97 in BPD and 97 or 96 in APD, respectively).