Table 3 Haplotype blocks frequencies and case-control association analysis with ASDs within the NLGN3 and NLGN4X genes

NLGN3

Males

Block1: rs11795613-rs4844285-rs4844286

X^A-X^G-X^T

0.579

0.716

0.032

6.74

0.009

0.017

1.834(1.158-2.907)

X^G-X^A-X^G

0.321

0.226

3.729

0.053

0.098

0.618(0.378-1.009)

X^G-X^A-X^T

0.079

0.042

1.975

0.160

0.462

0.515(0.202-1.317)

Females

Block 1: rs11795613-rs4844285

X^A-X^G

0.673

0.816

0.035

4.458

0.035

0.08

2.147(1.048-4.400)

X^G-X^A

0.327

0.184

4.458

0.035

0.08

0.446(0.227-0.954)

Block 2: rs4844286-rs5981079

X^T-X^T

0.557

0.678

0.221

2.573

0.109

0.244

1.671(0.895-3.121)

X^G-X^C

0.306

0.197

2.64

0.104

0.242

0.557(0.274-1.133)

X^T-X^C

0.137

0.125

0.044

0.834

0.996

0.902(0.370-2.199)

NLGN4X

Males

Block 2: rs1882409-rs5916352

X^G-X^C

0.700

0.695

0.035

0.009

0.925

1

0.977(0.607-1.575)

X^A-X^G

0.243

0.171

2.557

0.110

0.244

0.644(0.374-1.107)

X^A-X^C

0.057

0.134

5.17

0.023

0.068

2.546(1.112-5.832)

Females

Block 1**: rs6529901-rs5916397

X^A-X^A

0.514

0.595

0.145

1.122

0.290

0.665

1.386(0.756-2.539)

X^G-X^A

0.200

0.247

0.557

0.456

0.831

1.315(0.641-2.697)

X^G-X^G

0.269

0.129

5.083

0.024

0.060

0.404(0.180-0.904)