Long-term effects of environmentally relevant doses of 2,2',4,4',5,5' hexachlorobiphenyl (PCB153) on neurobehavioural development, health and spontaneous behaviour in maternally exposed mice

Table 1 Observations of physical development and behavioural tests in murine offspring

Physical markers of development	PND5	PND8	PND11	PND15	PND18	Week 16
Weight	+	+	+	+	+	+
Freeing of pinnae	+	+
Fur development	+	+
Incisor eruption		+	+	+
Eye opening			+	+
Behavioural testing	PND5	PND8	PND11	PND15	PND18	Week 16
Grasping reflex	+	+
Righting reflex	+	+
Climb/hang test	+	+	+
Auditory startle		+	+	+
Visual placing				+
Cliff drop aversion				+
Forelimb strength				+	+
Open field					+	+
Startle reflex (ASR/PPI)						+

Behavioural tests were performed on all pups in a litter from postnatal day (PND) 5 to PND18 and at 16 weeks of age. +: Signifies that the test was performed that day.

ISSN: 1744-9081