Behavioral and Brain Functions

Table 3 Association analysis of the 5 SNPs in females

From: Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

			Males
SNP name	Allele 1/2		N	Genotype			Allele		P-value		HWE P-value
				1/1	1/2	2/2	1	2	Genotype	Allele
rs2853550	A/G	Schizophrenia	231	5	54	172	64	398	0.18	0.096	0.78
				(0.02)	(0.23)	(0.74)	(0.14)	(0.86)
		Controls	732		7	147	578		161	1303	0.57
				(0.01)	(0.20)	(0.79)	(0.11)	(0.89)
rs1143634	A/G	Schizophrenia	227	1	17	209	19	435	0.46^(a)	0.84	0.32
				(0.00)	(0.07)	(0.92)	(0.04)	(0.96)
		Controls	738	1	63	674	65	1411			1.00
			(0.00)	(0.09)	(0.91)	(0.04)	(0.96)
rs1143633	C/T	Schizophrenia	225	52	104	69	208	242	0.013	0.0073	0.29
			(0.23)	(0.46)	(0.31)	(0.46)	(0.54)
		Controls	740	111	357	272	579	901			0.76
			(0.15)	(0.48)	(0.37)	(0.39)	(0.61)
rs1143630	T/G	Schizophrenia	225	6	59	160	71	379	0.97	0.83	0.80
			(0.03)	(0.26)	(0.71)	(0.16)	(0.84)
		Controls	736	18	190	528	226	1246			0.89
			(0.02)	(0.26)	(0.72)	(0.15)	(0.85)
rs16944	A/G	Schizophrenia	226	57	110	59	224	228	0.11	0.032	0.69
			(0.25)	(0.49)	(0.26)	(0.50)	(0.50)
		Controls	726	144	348	234	636	816			0.50
			(0.20)	(0.48)	(0.32)	(0.44)	(0.56)

(a) Calculated using Fisher's exact test.
SNP: single nucleotide polymorphism; HWE: Hardy-Weinberg Disequilibrium
Numbers in parentheses represent the frequencies of genotypes and alleles. Significant P-values (< 0.013) are shown in boldface.

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ISSN: 1744-9081

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