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Table 1 Kinetic parameters of tyrosine, tryptophan and alanine transport in fibroblasts from ADHD children

From: Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study

Kinetic parameter Amino acid Children with ADHD (n = 14) Controls (n = 13) p-value
V max Tyrosine 15.1 (11.5-25.4) 15.5 (7.8-21.5) 0.617
  Tryptophan 1.5 (1.1-3.0) 2.0 (1.3-4.7) 0.039*
  Alanine 42.8 (36.3-64.9) 32.0 (22.7-63.4) 0.031*
K m Tyrosine 20.0 (6.3) 18.8 (5.5) 0.645
  Tryptophan 13.6 (4.7) 21.1 (8.2) 0.010**
  Alanine 125.7 (41.2) 100.7 (30.1) 0.086
  1. The results are presented as median (range) for V max values and as mean (standard deviation) for K m values. ADHD, indicates Attention Deficit/Hyperactivity Disorder, V max , indicates maximal transport capacity (nmol/min/mg protein) and K m , indicates affinity of binding sites for a specific amino acid (μmol/l). *Statistically significant (p ≤ 0.05) **Statistically significant (p ≤ 0.01)