The genetic validation of heterogeneity in schizophrenia

Table 1 Derived data from SZGene for investigated genes and polymorphisms

	Gene	Polymorphism	Denomination	p-value	OR	95%CI	Cases				Control
							m/m	m/M	M/M	Sum	m/m	m/M	M/M	Sum
1	DRD2	rs6277(C/T)		5.71.E-06	1.4	(1.2-1.63)	178	266	130	574	225	484	332	1041
2	DRD2	rs1801028(G/C)		8.24.E-06	1.34	(1.11-1.61)	9	270	3770	4049	8	254	5420	5682
3	GRIN2B	rs1019385(T/G)	(200T/G)	4.70.E-05	0.69	(0.54-0.88)	85	256	161	502	114	257	95	466
4	TPH1	rs1800532(A/C)		7.99.E-05	1.25	(1.08-1.44)	324	609	306	1239	344	851	513	1708
5	MTHFR	rs1801133(T/C)	(C677T)	2.15.E-04	1.14	(1.03-1.25)	490	1672	1708	3870	550	2265	2536	5351
6	DTNBP1	rs2619528(A/G)	(P1765)	4.08.E-04	1.25	(1.01-1.56)	90	558	1049	1697	79	641	1485	2205
7	DRD4	120-bpTR(S/L)		3.80.E-03	0.81	(0.7-0.94)	55	374	807	1236	77	412	710	1199
8	PLXNA2	rs1327175(G/C)	0.043	0.76	(0.58-0.99)	12	221	1478	1711	15	280	1475	1770
9	DAOA	rs3916971(T/C)	0.045	0.84	(0.73-0.96)	169	401	274	844	213	457	252	922
10	HP	HP1/2		0.044	0.88	(0.8-0.98)	184	647	515	1346	324	995	699	2018

Abbreviation:
DRD2 = dopamine receptor D2, GRIN2B = glutamate receptor, ionotropic, N-methyl D-aspartate 2B, TPH1 = tryptophan hydroxylase 1, MTHFR = methylenetetrahydrofolate reductase, DTNBP1 = dystrobrevin binding protein 1, DRD4 = dopamine receptor D4, PLXNA2 = plexin A2, DAOA = D-amino acid oxidase activator, HP = haptoglobin
SCZ = Schizophrenia, NCs = Normal Controls, rs = Reference Single Nucleotide Polymorphism, bpTR = base pair Tandem Repeat, m = wild allele, M = mutant allele, S = Short allele, L = Long allele, SZGene = Schizophrenia Gene Database (http://www.szgene.org/), OR = Odds Ratio, CI = Confidential Interval

ISSN: 1744-9081