A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study

Table 4 Haplotype analysis of COMT rs4680 and rs165774 polymorphisms in patients with alcohol dependence

Haplotype rs4680/rs165774	Controls^c (%)	Alcohol^c (%)	Odds Ratio^a (P)	χ^{2 b}	P
A/A	147 (34.5)	126 (28.4)	1	3.794	0.051
A/G	93 (21.8)	89 (20.0)	1.116 (1.000)	0.419	0.517
G/A	5 (1.2)	1 (0.2)	0.233 (0.392)	3099	0.078
G/G	181 (42.5)	228 (51.4)	1.470 (0.042)	6.866	0.009
TOTAL	426	444		9.656	0.022

^a Odds ratio with respect to rs4680 A/rs165774 A haplotype which is more commonly associated with a normal phenotype
^b Likelihood ratio χ² test comparing haplotype frequency between groups when all other haplotypes were pooled (DF = 1, and DF = 3 for total χ²)
^c Haplotypes frequencies were estimated using JLIN version 1.6.0

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