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Table 4 Haplotype analysis of COMT rs4680 and rs165774 polymorphisms in patients with alcohol dependence

From: A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study

Haplotype rs4680/rs165774 Controlsc (%) Alcoholc (%) Odds Ratioa (P) χ2 b P
A/A 147 (34.5) 126 (28.4) 1 3.794 0.051
A/G 93 (21.8) 89 (20.0) 1.116 (1.000) 0.419 0.517
G/A 5 (1.2) 1 (0.2) 0.233 (0.392) 3099 0.078
G/G 181 (42.5) 228 (51.4) 1.470 (0.042) 6.866 0.009
TOTAL 426 444   9.656 0.022
  1. a Odds ratio with respect to rs4680 A/rs165774 A haplotype which is more commonly associated with a normal phenotype
  2. b Likelihood ratio χ2 test comparing haplotype frequency between groups when all other haplotypes were pooled (DF = 1, and DF = 3 for total χ2)
  3. c Haplotypes frequencies were estimated using JLIN version 1.6.0