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Table 4 Comparison of gene expression in anhedonic and resilient stressed mice versus non-stressed controls

From: Update in the methodology of the chronic stress paradigm: internal control matters

Category Function Anhedonic Resilient
   # Genes Up # Genes Down p-value # Genes Up # Genes Down p-value
Cellular Assembly and Organization transport of vesicles    N.S. 41   4.22E-07
  biogenesis of cytoskeleton    N.S. 35 3 5.41E-06
  morphogenesis of neurites    N.S. 33   7.25E-06
  formation of vesicles    N.S. 25   2.04E-05
  formation of filaments 11 13 4.47E-05    N.S.
  formation of neurites 4 8 8.47E-05    N.S.
Behavior cognition 9 6 2.62E-03 57 1 2.97E-06
  behavior 30 16 1.29E-04    N.S.
  learning    N.S. 48 1 2.13E-05
  psychological process of mice 23 10 2.49E-04    N.S.
  memory 10 5 3.01E-04    N.S.
  exploratory behavior of mice 6 1 1.80E-04 14   5.37E-04
Cellular Movement movement of brain cells    N.S. 30 1 3.40E-06
  migration of brain cells    N.S. 29 1 4.59E-06
Nervous System Development and Function development of neurites 18 4 1.67E-05 63   6.50E-06
  development of axons 11 4 3.10E-05 34   1.35E-03
  long-term potentiation 10 5 2.54E-03 50 3 1.60E-05
  long term depression 6 3 5.95E-04    N.S.
  synaptic transmission 13 6 2.77E-05 50   1.29E-04
  prepulse inhibition of mice 8 2 2.66E-06    N.S.
  coordination of mice 5 2 9.73E-05    N.S.
  memory 10 5 3.01E-04    N.S.
  spatial memory of mice 5 3 3.96E-04    N.S.
  neurological process 25 19 4.65E-08 107 4 1.30E-03
  neurotransmission 17 7 6.95E-07 57   1.30E-04
Neurological Disease seizures    N.S. 35 1 1.11E-04
  dyskinesia    N.S. 76 2 1.86E-04
  Huntington's disease 18 11 2.11E-06 75 1 2.06E-04
  neurological disorder 42 41 2.36E-06 258 11 5.50E-03
  neurodegeneration of neurons 8 3 2.75E-04 27   6.10E-04
  1. Gene expression data sets containing gene identity and corresponding expression values from an Illumina Technology analysis have been analyzed using the Ingenuity Pathway Analysis program. Out of 4795 eligible genes, the analysis generated lists of the most significant biological functions that are likely to be affected in anhedonic stressed or resilient stressed mice hippocampi, respectively. For selected detailed functions, the numbers of up-regulated and down-regulated genes are shown, as well as the significance score of the change in expression calculated as p-value of a right-tailed Fisher exact test. N.S. indicates a non-significant test (p-value > 1E-02)