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Table 4 Comparison of gene expression in anhedonic and resilient stressed mice versus non-stressed controls

From: Update in the methodology of the chronic stress paradigm: internal control matters

Category

Function

Anhedonic

Resilient

  

# Genes Up

# Genes Down

p-value

# Genes Up

# Genes Down

p-value

Cellular Assembly and Organization

transport of vesicles

  

N.S.

41

 

4.22E-07

 

biogenesis of cytoskeleton

  

N.S.

35

3

5.41E-06

 

morphogenesis of neurites

  

N.S.

33

 

7.25E-06

 

formation of vesicles

  

N.S.

25

 

2.04E-05

 

formation of filaments

11

13

4.47E-05

  

N.S.

 

formation of neurites

4

8

8.47E-05

  

N.S.

Behavior

cognition

9

6

2.62E-03

57

1

2.97E-06

 

behavior

30

16

1.29E-04

  

N.S.

 

learning

  

N.S.

48

1

2.13E-05

 

psychological process of mice

23

10

2.49E-04

  

N.S.

 

memory

10

5

3.01E-04

  

N.S.

 

exploratory behavior of mice

6

1

1.80E-04

14

 

5.37E-04

Cellular Movement

movement of brain cells

  

N.S.

30

1

3.40E-06

 

migration of brain cells

  

N.S.

29

1

4.59E-06

Nervous System Development and Function

development of neurites

18

4

1.67E-05

63

 

6.50E-06

 

development of axons

11

4

3.10E-05

34

 

1.35E-03

 

long-term potentiation

10

5

2.54E-03

50

3

1.60E-05

 

long term depression

6

3

5.95E-04

  

N.S.

 

synaptic transmission

13

6

2.77E-05

50

 

1.29E-04

 

prepulse inhibition of mice

8

2

2.66E-06

  

N.S.

 

coordination of mice

5

2

9.73E-05

  

N.S.

 

memory

10

5

3.01E-04

  

N.S.

 

spatial memory of mice

5

3

3.96E-04

  

N.S.

 

neurological process

25

19

4.65E-08

107

4

1.30E-03

 

neurotransmission

17

7

6.95E-07

57

 

1.30E-04

Neurological Disease

seizures

  

N.S.

35

1

1.11E-04

 

dyskinesia

  

N.S.

76

2

1.86E-04

 

Huntington's disease

18

11

2.11E-06

75

1

2.06E-04

 

neurological disorder

42

41

2.36E-06

258

11

5.50E-03

 

neurodegeneration of neurons

8

3

2.75E-04

27

 

6.10E-04

  1. Gene expression data sets containing gene identity and corresponding expression values from an Illumina Technology analysis have been analyzed using the Ingenuity Pathway Analysis program. Out of 4795 eligible genes, the analysis generated lists of the most significant biological functions that are likely to be affected in anhedonic stressed or resilient stressed mice hippocampi, respectively. For selected detailed functions, the numbers of up-regulated and down-regulated genes are shown, as well as the significance score of the change in expression calculated as p-value of a right-tailed Fisher exact test. N.S. indicates a non-significant test (p-value > 1E-02)