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Table 4 QTDT of rs1800498 alleles under an additive model at the DRD2 locus and QTDT of rs1495099 alleles under a recessive model at the PPP1R1B locus in affected sib-pair families 1

From: DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

ADI-R Subdomain DRD2 rs1800498 # Fam Observed Expected Z P 2 FDR threshold3
Social T 56 2909.0 2452.5 3.7 0.0002 0.017
Interaction C 56 1557.0 2013.5 −3.7 0.0002  
Verbal T 46 1364.0 1103.5 3.6 0.0004 0.033
Communication C 46 666.0 926.5 −3.6 0.0004  
Stereotyped T 56 876.0 754.5 3.1 0.0021 0.050
Behaviours C 56 502.0 623.5 −3.1 0.0021  
ADI-R Subdomain PPP1R1B rs1495099 # Fam Observed Expected Z P 2 FDR threshold 3
Social C 19 480.0 283.5 3.2 0.0016 0.017
Interaction G 36 535.0 579.5 −0.5 0.59 0.042
Nonverbal C 10 108.0 52.3 2.8 0.0046 0.025
Communication G 20 130.0 123.3 0.2 0.82 0.050
Stereotyped C 19 142.0 79.8 3.4 0.00072 0.0083
Behaviours G 36 176.0 200.3 −0.9 0.38 0.033
  1. 1All affected males were included for QTDT analyses
  2. 2P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined
  3. 3P-value ≤ FDR threshold is significant