DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

Table 4 QTDT of rs1800498 alleles under an additive model at the DRD2 locus and QTDT of rs1495099 alleles under a recessive model at the PPP1R1B locus in affected sib-pair families ¹

ADI-R Subdomain	*DRD2* rs1800498	# Fam	Observed	Expected	Z	P ²	FDR threshold³
Social	T	56	2909.0	2452.5	3.7	0.0002	0.017
Interaction	C	56	1557.0	2013.5	−3.7	0.0002
Verbal	T	46	1364.0	1103.5	3.6	0.0004	0.033
Communication	C	46	666.0	926.5	−3.6	0.0004
Stereotyped	T	56	876.0	754.5	3.1	0.0021	0.050
Behaviours	C	56	502.0	623.5	−3.1	0.0021
ADI-R Subdomain	*PPP1R1B rs1495099*	# Fam	Observed	Expected	Z	P ²	FDR threshold ³
Social	C	19	480.0	283.5	3.2	0.0016	0.017
Interaction	G	36	535.0	579.5	−0.5	0.59	0.042
Nonverbal	C	10	108.0	52.3	2.8	0.0046	0.025
Communication	G	20	130.0	123.3	0.2	0.82	0.050
Stereotyped	C	19	142.0	79.8	3.4	0.00072	0.0083
Behaviours	G	36	176.0	200.3	−0.9	0.38	0.033

¹All affected males were included for QTDT analyses
²P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined
³P-value ≤ FDR threshold is significant

ISSN: 1744-9081