Batch : 2ndwithdrawal | 3 days after boost | 3 weeks after boost |
|---|
VEH controls | 385 ± 118% | 157 ± 140% |
DAT-i mice | 2248 ± 866% ** | 156 ± 108% |
- Mean (±SEM, n = 12 per group) percent increase in plasma levels of DAT-aAbs titers in the second withdrawal compared to baseline, as a function of immunization group. Each mouse provided two samples differing for “timing” of withdrawal (i.e., baseline sample at PND 32 versus a second after-boost sample). The “batches” differed (see Experimental Scheme 1) for the second withdrawal, which was taken at PND 49 in batch I and PND 68 in batch II (i.e., 3 days after boost versus 3 weeks after boost). ** p < 0.01 between DAT-i and VEH control group.
