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Table 2 Reaction to novelty in VEH and DAT-i mice, in a novelty-seeking test

From: Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice

Parameter

Activity rate

Time (%) in novel

Crossing/min

VEH controls

3.79 ± 0.21

79.7 ± 1.09

2.55 ± 0.26

DAT-i mice

4.10 ± 0.22

78.6 ± 1.75

2.98 ± 0.33

  1. After a three-day familiarization to one side, mice had free-choice access to a novel side of the apparatus. Mean (±SEM, n = 12 per group) activity rate (number of beam interruptions per second), time (%) spent in the novel side, and frequency of crossing to the familiar side, measured via photo-beam interruptions by mice on the testing day.
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Behavioral and Brain Functions

ISSN: 1744-9081

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