Figure 5
From: The role of autophagy in Parkinson's disease: rotenone-based modeling
Rotenone-induced ultrastructural changes in SH-SY5Y. The ultrastructural changes in different rotenone-treated groups. A: high nucleo-cytoplasmic ratio and large nucleolus of SH-SY5Y cells of Con-group; B: normal mitochondria, rough endoplasmic reticulum and ribosomes (Con-group); C: mitochondria, rough endoplasmic reticulum, ribosomes and autophagic vacuoles (Arrow, Rot-1h group); D: mitochondria, rough endoplasmic reticulum, ribosomes and autophagic vacuoles (Arrow, Rot-2h group); E: rough endoplasmic reticulum, ribosomes and autophagic vacuoles (Arrow, Rot-6h group); F: mitochondrial swelling, mitochondrial crest fracture, mitochondrial vacuolar degeneration and autophagic vacuoles (Arrow, Rot-12h group); G: mitochondrial swelling, mitochondrial crest fracture, mitochondrial vacuolar degeneration and autophagic vacuoles (Arrow, Rot-24h group); H: mitochondrial swelling, mitochondrial crest fracture, mitochondrial vacuolar degeneration (Arrow, Rot-48h group); I: quantitative analysis of the rate of autophagic vacuoles-containing cells (*P < 0.05, compared to Con-group).