Figure 5

The effect of MPEP on the anxiety of ethanol naïve rats in the automated elevated plus maze and open field. The effect of MPEP (2.5, 5, 10, 20, and 30 mg/kg) on the percent open arm total time and entries of the automated elevated plus maze (A) and percentage of total time spent in the central zone of the open field by ethanol naïve rats (B). Each column represents the mean ± S.E.M [n = 8 for each group; EN = Control rats fed MLD without ethanol and treated with saline; EN + 2.5, EN + 5, EN + 10, EN + 20, EN + 30MPEP = ethanol naive group treated with respective doses of MPEP (mg/kg); *p<0.05, **p<0.01, ***p< 0.001 vs EN, One Way Analysis of Variance and post hoc Tukey’s test].