Figure 6

The effect of MPEP on the number of lines crossed in open field. The effect of MPEP (2.5, 5, 10, 20, and 30 mg/kg) on the number of lines crossed in the open field by ethanol withdrawn rats 7 hours after withdrawal (A) and ethanol naïve rats (B). Each column represents the mean ± S.E.M [n = 8 for each group; (A) EN = Control rats fed MLD without ethanol and treated with saline; EW = Ethanol Withdrawal (ethanol withdrawn group treated with normal saline); EW + 2.5, EW + 5,EW + 10, EW + 20, EW + 30MPEP = ethanol withdrawn group treated with respective doses of MPEP (mg/kg); (B) EN + 2.5, EN + 5,EN + 10, EN + 20, EN + 30MPEP = ethanol naive group treated with respective doses of MPEP (mg/kg); ***p < 0.001 vs EN, One Way Analysis of Variance and post hoc Tukey’s test].