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Table 7 Genotype and allele frequencies of the TPH2 SNP rs4565946 in normal population of different races

From: Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population

Polymorphism Number and frequency (%)
  Chinese (the paper) CHB (H) ASW (A) CEU (C) GIH (G) JPT (J) MEX (M) TSI (T)
TPH2 rs4565946
N 125 137 57 113 101 113 58 101
CC 65(52.0) 81 (46.6) 44 (77.2) 30 (26.5) 40 (39.6) 49 (43.4) 29 (50.0) 34 (33.7)
CT 53 (42.4) 63 (46.0) 10 (17.5) 51 (45.1) 47 (46.5) 51 (45.1) 27 (46.6) 43 (42.6)
TT 7 (5.6) 8 (5.8) 3 (5.3) 32 (28.3) 14 (13.9) 13 (11.5) 2 (3.4) 24 (23.8)
P a   0.975 0.004 <0.001 0.046 0.175 0.756 <0.001
C 183 (73.2) 195 (71.2) 98 (86.0) 111 (49.1) 127 (62.9) 149 (65.9) 85 (73.3) 111(55.0)
T 67 (26.8) 79 (28.8) 16 (14.0) 115 (50.9) 75 (37.1) 77 (34.1) 31 (26.7) 91 (45.0)
P b   0.604 0.007 <0.001 0.019 0.085 0.988 <0.001
TPH2 rs4570625
N 125 136 57 113 101 113 57 102
GG 24 (19.2) 30 (22.1) 26 (45.6) 73 (64.6) 63 (62.4) 28 (24.8) 25 (43.9) 60 (58.8)
GT 57 (45.6) 71 (52.2) 25 (43.9) 33 (29.2) 32 (31.7) 58 (51.3) 27 (47.4) 33 (32.4)
TT 44 (35.2) 35 (25.7) 6 (10.5) 7 (6.2) 6 (5.9) 27 (23.9) 5 (8.8) 9 (8.8)
P a   0.251 <0.001 <0.001 <0.001 0.150 <0.001 <0.001
G 105 (42.0) 131 (48.2) 77 (67.5) 179 (79.2) 158 (78.2) 114 (50.4) 77 (67.5) 153 (75.0)
T 145 (58.0) 141 (51.8) 37 (32.5) 47 (20.8) 44 (21.8) 112 (49.6) 37 (32.5) 51 (25.0)
P b   0.158 <0.001 <0.001 <0.001 0.065 <0.001 <0.001
  1. Abbreviations: TPH2, tryptophan hydroxylase2.
  2. CHB (H), Han Chinese in Beijing, China; ASW (A), African ancestry in Southwest USA; CEU (C), Utah residents with Northern and Western European ancestry from the CEPH collection; GIH (G), Gujarati Indians in Houston, Texas; JPT (J), Japanese in Tokyo, Japan; MEX (M), Mexican ancestry in Los Angeles, California; TSI (T), Tuscan in Italy;
  3. a Pearson Chi square test was used to calculate the p-values.
  4. b Chi square test was used to calculate the p-values. Continuity Correction was used when the minimum expected was <5.