Table 7 Genotype and allele frequencies of the TPH2 SNP rs4565946 in normal population of different races
Polymorphism | Number and frequency (%) | |||||||
|---|---|---|---|---|---|---|---|---|
Chinese (the paper) | CHB (H) | ASW (A) | CEU (C) | GIH (G) | JPT (J) | MEX (M) | TSI (T) | |
TPH2 rs4565946 | ||||||||
N | 125 | 137 | 57 | 113 | 101 | 113 | 58 | 101 |
CC | 65(52.0) | 81 (46.6) | 44 (77.2) | 30 (26.5) | 40 (39.6) | 49 (43.4) | 29 (50.0) | 34 (33.7) |
CT | 53 (42.4) | 63 (46.0) | 10 (17.5) | 51 (45.1) | 47 (46.5) | 51 (45.1) | 27 (46.6) | 43 (42.6) |
TT | 7 (5.6) | 8 (5.8) | 3 (5.3) | 32 (28.3) | 14 (13.9) | 13 (11.5) | 2 (3.4) | 24 (23.8) |
P a | 0.975 | 0.004 | <0.001 | 0.046 | 0.175 | 0.756 | <0.001 | |
C | 183 (73.2) | 195 (71.2) | 98 (86.0) | 111 (49.1) | 127 (62.9) | 149 (65.9) | 85 (73.3) | 111(55.0) |
T | 67 (26.8) | 79 (28.8) | 16 (14.0) | 115 (50.9) | 75 (37.1) | 77 (34.1) | 31 (26.7) | 91 (45.0) |
P b | 0.604 | 0.007 | <0.001 | 0.019 | 0.085 | 0.988 | <0.001 | |
TPH2 rs4570625 | ||||||||
N | 125 | 136 | 57 | 113 | 101 | 113 | 57 | 102 |
GG | 24 (19.2) | 30 (22.1) | 26 (45.6) | 73 (64.6) | 63 (62.4) | 28 (24.8) | 25 (43.9) | 60 (58.8) |
GT | 57 (45.6) | 71 (52.2) | 25 (43.9) | 33 (29.2) | 32 (31.7) | 58 (51.3) | 27 (47.4) | 33 (32.4) |
TT | 44 (35.2) | 35 (25.7) | 6 (10.5) | 7 (6.2) | 6 (5.9) | 27 (23.9) | 5 (8.8) | 9 (8.8) |
P a | 0.251 | <0.001 | <0.001 | <0.001 | 0.150 | <0.001 | <0.001 | |
G | 105 (42.0) | 131 (48.2) | 77 (67.5) | 179 (79.2) | 158 (78.2) | 114 (50.4) | 77 (67.5) | 153 (75.0) |
T | 145 (58.0) | 141 (51.8) | 37 (32.5) | 47 (20.8) | 44 (21.8) | 112 (49.6) | 37 (32.5) | 51 (25.0) |
P b | 0.158 | <0.001 | <0.001 | <0.001 | 0.065 | <0.001 | <0.001 | |