Figure 1

Morphological changes of rat hippocampal neuron induced by aluminium gluconate overload. (a) Representative graph of HE-stained CA1 section, 400×. Scale bars = 50 μm. Arrow indicates cell karyopyknosis. Dead nerve cells are characterized by eosinophilic changes; for instance, nerve cells became deep and red with nuclear pyknosis and nucleoli disappearance under light microscopy. (b) Data showing the cell death rate (n = 4). Data are expressed as mean ± SD of four individual experiments. ∗P < 0.05 compared with control group.